Linking major depression and the neural substrates of associative processing.
Linking major depression and the neural substrates of associative processing.
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DOI：
10.3758/s13415-016-0449-9
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Bar M
中科院分区：
文献类型：
--
作者：
Harel EV;Tennyson RL;Fava M;Bar M
有人提出，情绪与联想思维的广度相关。在这里，我们将在健康和抑郁的个体中测试这一假设。产生上下文关联涉及包括海马旁皮质（PHC）、压后复合体和内侧前额叶皮质在内的皮质区域网络。情绪，联想加工，其底层皮层基础设施之间的联系提供了一个有前途的途径，阐明认知障碍的机制，在重度抑郁症（MDD）。参与者包括15名急性重度抑郁发作的非药物个体和15名健康匹配的对照组。在一项功能性磁共振成像实验中，参与者观看了与特定背景（例如，海滩椅与水瓶），同时对每个对象的共性进行评级。进行分析以检查组间的脑激活和结构差异。与我们的假设相一致，控制显示出更大的激活的上下文关联网络相比，抑郁的参与者。此外，PHC结构体积与反刍倾向相关，抑郁症患者的海马亚区体积明显较小。令人惊讶的是，与对照组相比，抑郁的参与者表现出内嗅皮层（ERC）的活动增加。我们将这些发现整合在一个机械的帐户连接情绪和联想思维，并建议未来的方向。
It has been proposed that mood correlates with the breadth of associative thinking. Here we set to test this hypothesis in healthy and depressed individuals. Generating contextual associations engages a network of cortical regions including the parahippocampal cortex (PHC), retrosplenial complex, and medial prefrontal cortex. The link between mood, associative processing, and its underlying cortical infrastructure provides a promising avenue for elucidating the mechanisms underlying cognitive impairments in Major Depressive Disorder (MDD). Participants included fifteen non-medicated individuals with acute Major Depressive Episode and fifteen healthy matched controls. In an fMRI experiment, participants viewed images of objects that are either strongly or weakly associated with a specific context (e.g., a beach chair vs. a water bottle), while rating the commonality of each object. Analyses were performed to examine brain activation and structural differences between groups. Consistent with our hypothesis, controls showed greater activation of the contextual associations network compared with depressed participants. In addition, PHC structural volume was correlated with ruminative tendency and, volumes of the hippocampal subfields were significantly smaller in depressed participants. Surprisingly, depressed participants showed increased activity in the entorhinal cortex (ERC) compared with controls. We integrate these findings within a mechanistic account linking mood and associative thinking, and suggest directions for the future.
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影响因子：
16.2
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