Sex-dependent long-term effects of prepubescent stress on the posterior parietal cortex.
Sex-dependent long-term effects of prepubescent stress on the posterior parietal cortex.
复制标题
DOI：
10.1016/j.ynstr.2021.100295
复制
发表时间：
2021-05
影响因子：
5
通讯作者：
Lur G
中科院分区：
文献类型：
--
作者：
Fariborzi M;Park SB;Ozgur A;Lur G
青春期是大脑皮层发育旺盛的时期，也是对侮辱高度敏感的时期。为了确定性别如何影响青春期早期应激暴露的短期和长期结果，我们让青春期前(出生后第30天)的雄性和雌性小鼠接受重复的多个同时应激源(RMS)。在后顶叶皮质(PPC)，RMS导致深层兴奋性突触的消除，而表层抑制性突触密度的降低。这些短期效应与视觉空间工作记忆的降低不谋而合，而且在性别上是相似的。在30天的恢复期后，男性的兴奋性突触丢失和工作记忆受损的情况持续存在。相比之下，我们观察到女性的兴奋性传递和行为表现有显著的恢复。抑制性突触密度在两性中均有所恢复。我们还观察到，在接触RMS的女性中，有一种迟发性焦虑表型，这在男性中是不存在的。总体而言，我们的结果表明，青春期前应激对皮质突触和行为的长期影响存在显著的性别差异。
Adolescence is a time of intense cortical development and a period of heightened sensitivity to insult. To determine how sex affects the short- and long-term outcomes of early-adolescent stress exposure, we subjected prepubescent (postnatal day 30) male and female mice to repeated multiple concurrent stressors (RMS). In the posterior parietal cortex (PPC), RMS caused the elimination of excitatory synapses in deeper layers while inhibitory synapse density was predominantly diminished in superficial layers. These short-term effects coincided with reduced visuo-spatial working memory and were similar in both sexes. The loss of excitatory synapses and impaired working memory persisted in males past a 30-day recovery period. In contrast, we observed a remarkable recovery of excitatory transmission and behavioral performance in females. Inhibitory synapse density recovered in both sexes. We have also observed a late onset anxiety phenotype in RMS exposed females that was absent in males. Overall, our results indicate that there are marked sex differences in the long-term effects of prepubescent stress on cortical synapses and behavior.
登录
查看更多内容
影响因子：
3.3
作者：
Eiland, L.;Romeo, R. D.
通讯作者：
Romeo, R. D.
影响因子：
16.2
作者：
Giedd, Jay N.;Rapoport, Judith L.
通讯作者：
Rapoport, Judith L.
影响因子：
3.7
作者：
Eiland, Lisa;Ramroop, Johnny;Hill, Matthew N.;Manley, Jasmine;McEwen, Bruce S.
通讯作者：
McEwen, Bruce S.
由慢性早期应激产生的超兴趣和癫痫。
影响因子：
5
作者：
Dube, Celine M;Molet, Jenny;Singh-Taylor, Akanksha;Ivy, Autumn;Maras, Pamela M;Baram, Tallie Z
通讯作者：
Baram, Tallie Z
影响因子：
3.7
作者：
Dunkley BT;Sedge PA;Doesburg SM;Grodecki RJ;Jetly R;Shek PN;Taylor MJ;Pang EW
通讯作者：
Pang EW