Anti-arthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.).
Anti-arthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.).
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DOI：
10.1021/jf9027206
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发表时间：
2010-01-27
影响因子：
6.1
通讯作者：
Timmermann BN
中科院分区：
文献类型：
--
作者：
Funk JL;Frye JB;Oyarzo JN;Zhang H;Timmermann BN
姜黄（Curcuma longa L.，姜黄属植物的根茎含有两类次级代谢产物，姜黄素和研究较少的精油。先前已经在类风湿性关节炎（RA）的动物模型中鉴定了姜黄提取物中的姜黄素类化合物的有效抗关节炎作用，进行研究以确定姜黄精油（TEO）是否也使用相同的实验模型具有关节保护作用。当通过腹膜内注射给予提取物以最大化均匀递送时，粗品或精制的TEO提取物显著抑制患有链球菌细胞壁（SCW）诱导的关节炎的雌性大鼠的关节肿胀（90-100%抑制）。然而，这种抗关节炎作用伴随着显著的发病率和死亡率。口服20倍剂量的TEO是无毒的，但仅具有轻度关节保护作用（20%抑制）。这些结果不支持单独使用TEO治疗关节炎，而是确定了暴露于TEO的脊椎动物的潜在安全性问题。
Turmeric (Curcuma longa L., Zingiberaceae) rhizomes contain two classes of secondary metabolites, curcuminoids and the less well-studied essential oils. Having previously identified potent anti-arthritic effects of the curcuminoids in turmeric extracts in an animal model of rheumatoid arthritis (RA), studies were undertaken to determine whether the turmeric essential oils (TEO) were also joint protective using the same experimental model. Crude or refined TEO extracts dramatically inhibited joint swelling (90-100% inhibition) in female rats with streptococcal cell wall (SCW)-induced arthritis when extracts were administered via intraperitoneal injection to maximize uniform delivery. However, this anti-arthritic effect was accompanied by significant morbidity and mortality. Oral administration of a 20-fold higher dose TEO was non-toxic, but only mildly joint-protective (20% inhibition). These results do not support the isolated use of TEO for arthritis treatment, but, instead, identify potential safety concerns in vertebrates exposed to TEO.
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