A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men.
A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men.
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DOI：
10.1111/j.1532-5415.2009.02137.x
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发表时间：
2009-03
影响因子：
6.3
通讯作者：
Osteoporotic Fractures in Men Research Group
中科院分区：
文献类型：
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作者：
Ensrud KE;Ewing SK;Cawthon PM;Fink HA;Taylor BC;Cauley JA;Dam TT;Marshall LM;Orwoll ES;Cummings SR;Osteoporotic Fractures in Men Research Group
比较简约虚弱指数（组成部分：体重减轻，无法从椅子上站起来，精力不足[SOF指数]）与更复杂的CHS指数（组成部分：意外体重减轻，低握力，精力不足，缓慢和低体力活动）预测老年男性不良结局的有效性。前瞻性队列研究美国6家中心3132例≥67岁男性使用SOF指数和与CHS指数相似的标准分类为健壮、中期或虚弱。福尔斯1年内每3年报告一次。在1年时确定残疾（在进行IADL时出现≥1项新损害）。3年随访期间确定的骨折和死亡。接受者工作特征曲线分析的曲线下面积（AUC）统计数据比较了包含SOF指数与CHS指数的模型。根据任一指数定义的虚弱证据越多，不良结局风险越高。虚弱男性的年龄调整后复发性福尔斯（优势比[OR] 3.0-3.6）、残疾（优势比[OR] 5.3-7.5）、非脊柱骨折（风险比[HR] 2.2-2.3）和死亡（HR 2.5-3.5）风险更高（所有模型P<0.001）。AUC比较显示，SOF指数模型与CHS指数模型在区分福尔斯（AUC=0.63，P= 0.97）、残疾（AUC=0.68，P=0.86）、非脊柱骨折（AUC=0.63，P=0.90）或死亡（SOF指数模型AUC=0.71，CHS指数模型AUC= 0.72，P=0.19）方面无差异。简单的SOF指数预测男性福尔斯、残疾、骨折和死亡的风险，以及更复杂的CHS指数。
To compare validity of a parsimonious frailty index (components: weight loss, inability to rise from a chair, and poor energy [SOF index]) with that of the more complex CHS index (components: unintentional weight loss, low grip strength, poor energy, slowness, and low physical activity) for prediction of adverse outcomes in older men. Prospective cohort study Six U.S. centers 3132 men ≥67 years Men classified as robust, intermediate stage or frail using SOF index and criteria similar to those used in CHS index. Falls reported tri-annually for 1 year. Disability (≥1 new impairment in performing IADL) ascertained at 1 year. Fractures and deaths ascertained during 3 years of follow-up. Area under the curve (AUC) statistics from receiver operating characteristic curve analysis compared for models containing SOF index versus CHS index. Greater evidence of frailty as defined by either index was associated with increased risks of adverse outcomes. Frail men had a higher age-adjusted risk of recurrent falls (odds ratio [OR] 3.0–3.6), disability (OR 5.3–7.5), nonspine fracture (hazards ratio [HR] 2.2–2.3), and death (HR 2.5–3.5) (P<0.001 for all models). AUC comparisons revealed no differences between models with SOF index versus models with CHS index in discriminating falls (AUC=0.63, P= 0.97), disability (AUC=0.68, P=0.86), nonspine fracture (AUC=0.63, P=0.90), or death (AUC=0.71 for model with SOF index and 0.72 for model with CHS index, P=0.19). The simple SOF index predicts risk of falls, disability, fracture and mortality in men as well as the more complex CHS index.
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影响因子：
--
作者：
Ensrud, KE;Cauley, J;Cummings, SR
通讯作者：
Cummings, SR
DOI：
10.1046/j.1532-5415.2003.51558.x
发表时间：
2003-12-01
影响因子：
6.3
作者：
Ensrud, KE;Ewing, SK;Cummings, SR
通讯作者：
Cummings, SR
DOI：
10.1093/gerona/61.3.262
发表时间：
2006-03-01
影响因子：
5.1
作者：
Bandeen-Roche, K;Xue, QL;Fried, LP
通讯作者：
Fried, LP
影响因子：
2.2
作者：
Orwoll, E;Blank, JB;Stone, K
通讯作者：
Stone, K
DOI：
10.1111/j.1532-5415.2004.52174.x
发表时间：
2004-04-01
影响因子：
6.3
作者：
Ferrucci, L;Guralnik, JM;Walston, JD
通讯作者：
Walston, JD