A comparison of conversion rates, clinical profiles and predictors of outcomes in two independent samples of individuals at clinical high risk for psychosis in China.
A comparison of conversion rates, clinical profiles and predictors of outcomes in two independent samples of individuals at clinical high risk for psychosis in China.
复制标题
中国精神病临床高风险个体的两个独立样本的转化率、临床特征和结果预测因子的比较
DOI：
10.1016/j.schres.2017.11.029
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发表时间：
2018-07
影响因子：
4.5
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Li H;Zhang T;Xu L;Tang Y;Cui H;Wei Y;Tang X;Woodberry KA;Shapiro DI;Li C;Seidman LJ;Wang J
在以前的流行病学研究中，我们报告了上海市精神卫生中心（SMHC，“2011年队列”）“临床高危”（CRD）个体的确定和结局。目前的研究比较了该样本的人口统计学和临床特征，包括转换率，随后招募的独立样本和西方样本的已发表数据。基于筛选和半结构化访谈，选择了100名受试者的新样本（“2013年队列”）。两项研究均使用前驱综合征结构化访谈（SIPS）进行评估，并进行了为期两年的自然随访。比较两个队列的转换率、人口统计学和临床特征、精神病风险症状和精神病转换的风险因素。2013年队列受试者中有91例（91%）完成了两年的临床随访，25例（91例中的27.5%）在随访期间转化为精神障碍。2013年和2011年队列之间转换为完全精神病的比较显示，转换时间无显著差异（成对比较：χ2 = 0.3，p = 0.562）。两项队列研究均显示，基线时临床症状更严重且功能下降的精神分裂症受试者更有可能转化为精神病。这个新的独立中国样本的转化率与非中国样本和2011年队列报告的转化率相似。未来的研究需要检查是否实施早期干预的精神病/前驱症状降低精神病的风险，降低转换率。
In a previous epidemiological study, we reported on the ascertainment and outcomes of “clinical high risk” (CHR) individuals at the Shanghai Mental Health Center (SMHC, “2011 cohort”). The current study compares demographic and clinical characteristics, including conversion rates, of this sample with a subsequently recruited, independent CHR sample and with published data from western samples. A new sample of 100 CHR subjects (“2013 cohort”) was selected based on screening and semi-structured interviews. Both studies used the Structured Interview for Prodromal Syndromes (SIPS) for CHR assessment and conducted a naturalistic two-year follow-up. The two cohorts were compared on conversion rates, demographic and clinical characteristics, psychosis risk symptoms, and risk factors for psychotic conversion. Ninety one (91%) of the 2013 cohort subjects completed the clinical two-year follow-up and 25 (27.5% of the 91) converted to a psychotic disorder over the follow-up period. A comparison of conversions to full psychosis between the 2013 and the 2011 cohorts showed no significant difference in time to conversion (Pairwise comparison: χ2 = 0.3, p = 0.562). Both cohort studies showed that CHR subjects with more severe clinical symptoms at baseline and decline in functioning were more likely to convert to psychosis. Conversion rates in this new, independent Chinese sample are similar to those reported in non-Chinese samples and to the 2011 cohort. Future research is needed to examine whether the implementation of early intervention for CHR/prodromal symptoms reduces the risk of psychosis and decreases the conversion rate.
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作者：
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影响因子：
4.5
作者：
Zhang T;Li H;Woodberry KA;Seidman LJ;Zheng L;Li H;Zhao S;Tang Y;Guo Q;Lu X;Zhuo K;Qian Z;Chow A;Li C;Jiang K;Xiao Z;Wang J
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