Perfusion MRI of brain tumours: a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging.
Perfusion MRI of brain tumours: a comparative study of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast imaging.
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DOI：
10.1007/s00234-009-0616-6
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发表时间：
2010-04
期刊：
影响因子：
2.8
通讯作者：
Larsson, Elna-Marie
中科院分区：
文献类型：
--
作者：
Jarnum, Hanna;Steffensen, Elena G.;Knutsson, Linda;Frund, Ernst-Torben;Simonsen, Carsten Wiberg;Lundbye-Christensen, Soren;Shankaranarayanan, Ajit;Alsop, David C.;Jensen, Finn Taagehoj;Larsson, Elna-Marie
本研究的目的是比较非侵入性3D伪连续动脉自旋标记（PC ASL）技术与临床建立的动态磁敏感对比灌注磁共振成像（DSC-MRI）用于评价脑肿瘤。在3 T条件下，使用DSC-MRI和PC ASL（全脑覆盖）对28例对比度增强脑肿瘤患者进行了前瞻性研究。肿瘤中信号增强的视觉定性评价评分为0 - 3分（0 =与白色物质相比无信号增强，3 =明显信号增强，信号强度等于或高于灰质/基底节）。肿瘤中的敏感性伪影的程度从0到2评分（0 =无敏感性伪影，2 =广泛的敏感性伪影（最大直径> 2cm））。使用标准化肿瘤血流值（ASL nTBF，DSC nTBF）进行定量分析：最大信号增强区域中感兴趣区域（ROI）的平均值/小脑中ROI的平均值。PC ASL和DSC相对脑血流量之间信号增强的总视觉评分无差异（p=0.12）。ASL的可分辨性伪影评分低于DSC-MRI（p=0.03）。DSC nTBF和ASL nTBF值之间具有良好的相关性，相关系数为0.82。PC ASL是评价脑肿瘤灌注的DSC-MRI的替代方法。该方法比DSC-MRI具有更少的敏感性伪影，并且可以用于肾衰竭患者，因为不需要注射造影剂。
The purpose of this study was to compare the non-invasive 3D pseudo-continuous arterial spin labelling (PC ASL) technique with the clinically established dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC-MRI) for evaluation of brain tumours. A prospective study of 28 patients with contrast-enhancing brain tumours was performed at 3 T using DSC-MRI and PC ASL with whole-brain coverage. The visual qualitative evaluation of signal enhancement in tumour was scored from 0 to 3 (0 = no signal enhancement compared with white matter, 3 = pronounced signal enhancement with equal or higher signal intensity than in grey matter/basal ganglia). The extent of susceptibility artefacts in the tumour was scored from 0 to 2 (0 = no susceptibility artefacts and 2 = extensive susceptibility artefacts (maximum diameter>2 cm)). A quantitative analysis was performed with normalised tumour blood flow values (ASL nTBF, DSC nTBF): mean value for region of interest (ROI) in an area with maximum signal enhancement/the mean value for ROIs in cerebellum. There was no difference in total visual score for signal enhancement between PC ASL and DSC relative cerebral blood flow (p=0.12). ASL had a lower susceptibility-artefact score than DSC-MRI (p=0.03). There was good correlation between DSC nTBF and ASL nTBF values with a correlation coefficient of 0.82. PC ASL is an alternative to DSC-MRI for the evaluation of perfusion in brain tumours. The method has fewer susceptibility artefacts than DSC-MRI and can be used in patients with renal failure because no contrast injection is needed.
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影响因子：
14.5
作者：
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