The QUASAR reproducibility study, Part II: Results from a multi-center Arterial Spin Labeling test-retest study.
The QUASAR reproducibility study, Part II: Results from a multi-center Arterial Spin Labeling test-retest study.
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DOI：
10.1016/j.neuroimage.2009.07.068
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发表时间：
2010-01-01
期刊：
影响因子：
5.7
通讯作者：
Golay, Xavier
中科院分区：
文献类型：
--
作者：
Petersen, Esben Thade;Mouridsen, Kim;Golay, Xavier
动脉自旋标记（ASL）是一种使用磁性标记的血液水作为内源性示踪剂来测量灌注的方法。由于完全无创，该技术对于健康和患病个体的脑血流的纵向研究或作为代谢的替代标记物是有吸引力的。到目前为止，由于该方法的SNR通常较低，以及获得脑血流量（CBF）定量测量所需的用户相关分析的潜在问题，ASL主要限于专科中心。在这里，我们评估了ASL（称为动脉区域的定量星星标记或QUASAR）的特定实现，这是一种在来自世界各地的大型测试-再测试研究中提供CBF的用户独立量化的方法，被称为“QUASAR再现性研究”。总共有28个位于亚洲、欧洲和北美的研究中心参与，共扫描了284名健康志愿者。通过使用自动计划工具确保最小的操作者依赖性，并评估其在多中心试验中的准确性和潜在有用性。使用自动计划工具实现了两次治疗之间的准确重新定位，显示平均位移为1.87± 0.95 mm，旋转为1.56±0.66°。平均灰质CBF为47.4±7.5 [ml/100 g/min]，受试者间标准差SDb = 5.5 [ml/100 g/min]，受试者内标准差SDw = 4.7 [ml/100 g/min]。相应的重复性为13.0 [ml/100 g/min]，并在先前研究的范围内。
Arterial Spin Labeling (ASL) is a method to measure perfusion using magnetically labeled blood water as an endogenous tracer. Being fully non-invasive, this technique is attractive for longitudinal studies of cerebral blood flow in healthy and diseased individuals, or as a surrogate marker of metabolism. So far, ASL has been restricted mostly to specialist centers due to a generally low SNR of the method and potential issues with user-dependent analysis needed to obtain quantitative measurement of cerebral blood flow (CBF). Here, we evaluated a particular implementation of ASL (called Quantitative STAR labeling of Arterial Regions or QUASAR), a method providing user independent quantification of CBF in a large test-retest study across sites from around the world, dubbed “The QUASAR reproducibility study”. Altogether, 28 sites located in Asia, Europe and North America participated and a total of 284 healthy volunteers were scanned. Minimal operator dependence was assured by using an automatic planning tool and its accuracy and potential usefulness in multi-center trials was evaluated as well. Accurate repositioning between sessions was achieved with the automatic planning tool showing mean displacements of 1.87±0.95mm and rotations of 1.56±0.66°. Mean gray matter CBF was 47.4±7.5 [ml/100g/min] with a between subject standard variation SDb = 5.5 [ml/100g/min] and a within subject standard deviation SDw = 4.7 [ml/100g/min]. The corresponding repeatability was 13.0 [ml/100g/min] and was found to be within the range of previous studies.
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影响因子：
14.5
作者：
LEENDERS, KL;PERANI, D;JONES, T
通讯作者：
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DOI：
10.1152/ajpheart.01037.2004
发表时间：
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