Exploring the origin and degree of genetic isolation of Anopheles gambiae from the islands of São Tomé and Príncipe, potential sites for testing transgenic-based vector control.
Exploring the origin and degree of genetic isolation of Anopheles gambiae from the islands of São Tomé and Príncipe, potential sites for testing transgenic-based vector control.
复制标题
DOI：
10.1111/j.1752-4571.2008.00048.x
复制
发表时间：
2008-11
影响因子：
4.1
通讯作者：
Caccone A
中科院分区：
文献类型：
--
作者：
Marshall JC;Pinto J;Charlwood JD;Gentile G;Santolamazza F;Simard F;Della Torre A;Donnelly MJ;Caccone A
疟疾蚊媒冈比亚按蚊（Anopheles gambiae sensu stricto）的岛屿和大陆种群之间的进化过程引起了人们极大的兴趣，因为岛屿可能是初步应用基于转基因的媒介控制策略的合适场所。位于西非海岸的圣多美和普林西比近年来受到如此关注。本研究调查了 An 的孤立程度。冈比亚船队根据线粒体和核糖体 DNA 分子数据确定这些岛屿和大陆之间的人口。我们确定了这些岛屿人口可能源自的大陆地区。为此，我们使用 FST 值、单倍型网络和嵌套进化枝分析来估计迁移率和模式。这两个标记的单倍型在地理上广泛分布于整个非洲大陆。结果表明，圣多美和普林西比的种群与非洲大陆种群相对隔离，这表明它们是转基因个体测试释放的有希望的地点。这些岛屿人口可能来自两次独立的大陆迁徙。这一结果是在圣多美和普林西比的非洲奴隶贸易历史背景下讨论的。
The evolutionary processes at play between island and mainland populations of the malaria mosquito vector Anopheles gambiae sensu stricto are of great interest as islands may be suitable sites for preliminary application of transgenic-based vector control strategies. São Tomé and Príncipe, located off the West African coast, have received such attention in recent years. This study investigates the degree of isolation of An. gambiae s.s. populations between these islands and the mainland based on mitochondrial and ribosomal DNA molecular data. We identify possible continental localities from which these island populations derived. For these purposes, we used FST values, haplotype networks, and nested clade analysis to estimate migration rates and patterns. Haplotypes from both markers are geographically widespread across the African continent. Results indicate that the populations from São Tomé and Príncipe are relatively isolated from continental African populations, suggesting they are promising sites for test releases of transgenic individuals. These island populations are possibly derived from two separate continental migrations. This result is discussed in the context of the history of the African slave trade with respect to São Tomé and Príncipe.
登录
查看更多内容
DOI：
10.4269/ajtmh.2008.78.169
发表时间：
2008-01-01
影响因子：
3.3
作者：
Calzetta, Maria;Santolamazza, Federica;Petrarca, Vincenzo
通讯作者：
Petrarca, Vincenzo
影响因子：
1.5
作者：
BRYAN, JH;DIDECO, MA;COLUZZI, M
通讯作者：
COLUZZI, M
影响因子：
3.8
作者：
Donnelly, MJ;Pinto, J;Lehmann, T
通讯作者：
Lehmann, T
影响因子：
4.9
作者：
Clement, M;Posada, D;Crandall, KA
通讯作者：
Crandall, KA
影响因子：
2.6
作者：
Beebe, NW;Maung, J;Cooper, RD
通讯作者：
Cooper, RD