Irradiation in adulthood as a new model of schizophrenia.
Irradiation in adulthood as a new model of schizophrenia.
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DOI：
10.1371/journal.pone.0002283
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发表时间：
2008-05-28
期刊：
影响因子：
3.7
通讯作者：
Mori N
中科院分区：
文献类型：
--
作者：
Iwata Y;Suzuki K;Wakuda T;Seki N;Thanseem I;Matsuzaki H;Mamiya T;Ueki T;Mikawa S;Sasaki T;Suda S;Yamamoto S;Tsuchiya KJ;Sugihara G;Nakamura K;Sato K;Takei N;Hashimoto K;Mori N
流行病学研究表明，辐射照射可能是成年人患精神分裂症的一个潜在危险因素。在这里，我们调查了成年照射大鼠是否会引起与精神分裂症相关的行为异常。采用俯卧位雄性大鼠，分6次照射前脑（包括脑室下区（SVZ）和颗粒下区（SGZ）），总剂量为15-戈伊，共照射3周。行为，免疫组织化学和神经化学研究进行了三个月后，分次电离辐射。分次电离辐射后3个月，照射大鼠SVZ和SGZ区的BrdU阳性细胞总数显着低于对照组（假照射）大鼠。多巴胺能激动剂甲基苯丙胺，但不是N-甲基-D-天冬氨酸（NMDA）受体拮抗剂地佐环平，管理后的多动症，显着增强辐射大鼠，虽然自发运动辐射大鼠显着低于对照组。行为异常，包括听觉感觉门控缺陷，社会互动缺陷，和工作记忆缺陷，观察到在照射大鼠。目前的研究表明，在成年期的照射引起的行为异常精神分裂症相关，并减少成年神经再生的照射可能与精神分裂症样行为的大鼠。
Epidemiological studies suggest that radiation exposure may be a potential risk factor for schizophrenia in adult humans. Here, we investigated whether adult irradiation in rats caused behavioral abnormalities relevant to schizophrenia. A total dose of 15-Gy irradiation in six fractionations during 3 weeks was exposed to the forebrain including the subventricular zone (SVZ) and subgranular zone (SGZ) with male rats in the prone position. Behavioral, immunohistochemical, and neurochemical studies were performed three months after fractionated ionizing irradiation. Three months after fractionated ionizing irradiation, the total numbers of BrdU-positive cells in both the SVZ and SGZ zones of irradiated rats were significantly lower than those of control (sham-irradiated) rats. Hyperactivity after administration of the dopaminergic agonist methamphetamine, but not the N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine, was significantly enhanced in the irradiated rats although spontaneous locomotion in the irradiated rats was significantly lower than that of controls. Behavioral abnormalities including auditory sensory gating deficits, social interaction deficits, and working memory deficits were observed in the irradiated rats. The present study suggests that irradiation in adulthood caused behavioral abnormalities relevant to schizophrenia, and that reduction of adult neurogenesis by irradiation may be associated with schizophrenia-like behaviors in rats.
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5.3
作者：
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