Magnetic resonance spectroscopy of limbic structures displays metabolite differences in young unaffected relatives of schizophrenia probands.
Magnetic resonance spectroscopy of limbic structures displays metabolite differences in young unaffected relatives of schizophrenia probands.
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DOI：
10.1016/j.schres.2011.05.024
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发表时间：
2011-09
影响因子：
4.5
通讯作者：
Ho, Beng-Choon
中科院分区：
文献类型：
--
作者：
Capizzano, Aristides A.;Toscano, Juana L. Nicoll;Ho, Beng-Choon
关键词：
精神分裂症患者的影像学研究显示额颞叶脑容量不足，而患者和未受影响的生物亲属的磁共振波谱（MRS）研究发现海马和额叶神经元标记物N-乙酰天冬氨酸（NAA）减少，含胆碱磷脂增加。使用3 T MR扫描仪，我们确定了边缘区域（前扣带皮层（ACC）和左海马）的代谢产物谱的36个未受影响的，青少年/年轻的成年亲属的精神分裂症先证者（第一度=16，第二度=20）和25名健康对照组没有精神分裂症家族史。各组对左侧海马（F=6.11，p≤0.02）和ACC（F=4.89，p≤0.03）的NAA/Cho比值以及左侧海马Cho/Cr比值均有显著主效应（F=5.55，p≤0.02）。与年龄和性别匹配的无精神分裂症家族史的健康对照组相比，先证者的一级亲属比二级亲属具有更大的MRS代谢物偏差。在生物学亲属中，精神分裂症先证者（或精神分裂症易感性较高）的家族接近程度越大，NAA/Cho的逐步降低和Cho/Cr比值的升高越相关。在年轻的非精神病生物学亲属中观察到的边缘系统代谢物变化可能与共享的遗传脆弱性因素有关，并可能有助于早期识别精神分裂症的一级和二级预防。
Imaging studies of schizophrenia patients showed fronto-temporal brain volume deficits, while magnetic resonance spectroscopy (MRS) studies of patients and unaffected biological relatives have found a decrement of the neuronal marker N-acetyl-aspartate (NAA) in the hippocampus and frontal lobes, and increased choline-containing phospholipids. Using a 3 T MR scanner, we determined the metabolite profile within limbic regions (anterior cingulate cortex (ACC) and left hippocampus) of 36 unaffected, adolescent/young adult relatives of schizophrenia probands (first-degree=16, second-degree=20) and 25 healthy controls with no family history of schizophrenia. Significant main effects of group were found on NAA/Cho ratios for both the left hippocampus (F=6.11, p≤0.02) and ACC (F=4.89, p≤0.03) as well as for the left hippocampus Cho/Cr ratio (F=5.55, p≤0.02). Compared to age and sex matched healthy controls without a family history of schizophrenia, first-degree relatives of probands had greater MRS metabolite deviations than second-degree relatives. Greater familial proximity to the schizophrenia proband (or higher schizophrenia susceptibility) among biological relatives was associated with stepwise lowering of NAA/Cho and elevations in Cho/Cr ratios. The observed limbic metabolite changes among young, nonpsychotic biological relatives are likely related to shared genetic vulnerability factors, and may assist in the early identification of schizophrenia for primary and secondary prevention.
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