Vascular mechanisms leading to progression of mild cognitive impairment to dementia after COVID-19: Protocol and methodology of a prospective longitudinal observational study.
Vascular mechanisms leading to progression of mild cognitive impairment to dementia after COVID-19: Protocol and methodology of a prospective longitudinal observational study.
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DOI：
10.1371/journal.pone.0289508
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
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轻度认知障碍 (MCI) 是痴呆症的前驱阶段，影响着全球高达 20% 的老年人口。 MCI 患者每年转化为痴呆的率为 15-20%。因此，增加 MCI 向痴呆症转化的情况是最重要的公共卫生问题。 COVID-19 大流行对我们的老龄化人口产生了重大影响，认知能力下降是急性感染恢复后的主要并发症之一。最近的研究结果表明，COVID-19 增加了老年人从轻度认知障碍 (MCI) 转变为痴呆症的比率。因此，我们的目标是揭示 COVID-19 引起的认知障碍和进展为痴呆的机制，为未来可能减轻 COVID-19 引起的认知能力下降的治疗目标铺平道路。俄克拉荷马大学健康科学中心进行了一项前瞻性纵向研究。患者在神经内科进行筛查，并且必须在研究入组前获得 MCI 的正式诊断和 MRI 成像。符合纳入标准的患者将被纳入并在首次就诊后 18 个月进行随访。一次就诊和 18 个月的随访将包括一系列综合的血管和认知测量，包括外周内皮功能（血流介导的扩张、激光散斑对比成像）、视网膜和脑血管血流动力学（动态血管视网膜分析、功能性近红外光谱）以及流体和结晶智能（NIH-Toolbox、n-back）。多重逻辑回归将用于主要纵向数据分析，以确定与 COVID-19 相关的神经血管耦合损伤和白质高信号负担的增加是否会导致痴呆的进展。
Mild cognitive impairment (MCI) is a prodromal stage to dementia, affecting up to 20% of the aging population worldwide. Patients with MCI have an annual conversion rate to dementia of 15–20%. Thus, conditions that increase the conversion from MCI to dementia are of the utmost public health concern. The COVID-19 pandemic poses a significant impact on our aging population with cognitive decline as one of the leading complications following recovery from acute infection. Recent findings suggest that COVID-19 increases the conversion rate from MCI to dementia in older adults. Hence, we aim to uncover a mechanism for COVID-19 induced cognitive impairment and progression to dementia to pave the way for future therapeutic targets that may mitigate COVID-19 induced cognitive decline. A prospective longitudinal study is conducted at the University of Oklahoma Health Sciences Center. Patients are screened in the Department of Neurology and must have a formal diagnosis of MCI, and MRI imaging prior to study enrollment. Patients who meet the inclusion criteria are enrolled and followed-up at 18-months after their first visit. Visit one and 18-month follow-up will include an integrated and cohesive battery of vascular and cognitive measurements, including peripheral endothelial function (flow-mediated dilation, laser speckle contrast imaging), retinal and cerebrovascular hemodynamics (dynamic vessel retinal analysis, functional near-infrared spectroscopy), and fluid and crystalized intelligence (NIH-Toolbox, n-back). Multiple logistic regression will be used for primary longitudinal data analysis to determine whether COVID-19 related impairment in neurovascular coupling and increases in white matter hyperintensity burden contribute to progression to dementia.
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DOI：
10.1038/s41579-022-00846-2
发表时间：
2023-03
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
通讯作者：
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影响因子：
6.7
作者：
Cheng ST
通讯作者：
Cheng ST
DOI：
10.1016/j.jstrokecerebrovasdis.2022.106333
发表时间：
2022-02-11
影响因子：
2.5
作者：
Andere, Ariana;Jindal, Gaurav;Cutting, Shawna
通讯作者：
Cutting, Shawna
影响因子：
5.6
作者：
Csiszar, Anna;Yabluchanskiy, Andriy;Tarantini, Stefano
通讯作者：
Tarantini, Stefano
影响因子：
11
作者：
Al-Hakeim, Hussein Kadhem;Al-Rubaye, Haneen Tahseen;Al-Hadrawi, Dhurgham Shihab;Almulla, Abbas F.;Maes, Michael
通讯作者：
Maes, Michael