Atlas of receptor genes expressed by the bovine morula and corresponding ligand-related genes expressed by uterine endometrium.
Atlas of receptor genes expressed by the bovine morula and corresponding ligand-related genes expressed by uterine endometrium.
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DOI：
10.1002/mrd.23534
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发表时间：
2021-10
影响因子：
2.5
通讯作者：
Hansen PJ
中科院分区：
文献类型：
--
作者：
Sang L;Xiao Y;Jiang Z;Forde N;Tian XC;Lonergan P;Hansen PJ
哺乳动物胚胎的调控涉及母体输卵管和子宫内膜产生的细胞信号分子。本研究检测了妊娠第5天和第6天的牛桑葚胚和第5天母体子宫内膜的转录组数据，以确定桑葚胚表达的受体基因和子宫内膜中相应配体相关基因的表达。在桑葚中共鉴定出175个受体基因，其中48个编码生长因子或WNT信号分子，25个编码细胞因子和趋化因子，35个参与近胞苷和基质细胞信号传导，25个编码小分子受体。一些高表达的子宫内膜配体和胚胎受体基因对包括MDK及其受体ITGB1、SDC4和LRP2、WNT5A （RYK）、VEGFA （ITGB1）、GPI （AMFR）以及刺猬蛋白IHH和DHH （hip）。高表达的小分子受体是GPRC5C（视黄酸受体）、PGRMC1（黄体酮）和CHRNB2（乙酰胆碱）。桑葚表达的细胞信号配体编码基因也有84个，其中表达量最高的是GPI、AIMP1、TIMP1、IK和CCN2。受体和配体基因图谱将有助于了解胚胎和母亲之间沟通的细节，这是最佳胚胎发育的基础。
Regulation of the mammalian embryo involves cell‐signaling molecules produced by the maternal oviduct and endometrium. Here, datasets on the transcriptome of the gestational Days 5 and 6 bovine morula and Day 5 maternal endometrium were examined to identify receptor genes expressed by the morula and expression of the corresponding ligand‐related genes in the endometrium. A total of 175 receptor genes were identified in the morula, including 48 encoding for growth factors or WNT signaling molecules, 25 for cytokines and chemokines, 35 involved in juxtacrine and matricellular signaling and 25 encoding for receptors for small molecules. Some of the highly‐expressed pairs of endometrial ligand and embryo receptor genes included MDK and its receptors ITGB1, SDC4 and LRP2, WNT5A (RYK), VEGFA (ITGB1), GPI (AMFR), and the hedgehog proteins IHH and DHH (HHIP). The most highly expressed receptors for small molecules were GPRC5C (retinoic acid receptor), PGRMC1 (progesterone), and CHRNB2 (acetylcholine). There were also 84 genes encoding for cell signaling ligands expressed by the morula, with the most highly expressed being GPI, AIMP1, TIMP1, IK, and CCN2. The atlas of receptor and ligand genes should prove useful for understanding details of the communication between the embryo and mother that underlies optimal embryonic development.
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DOI：
10.1146/annurev-animal-021419-084010
发表时间：
2020-01-01
期刊：
ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 8, 2020
影响因子：
--
作者：
Hansen，Peter J.
通讯作者：
Hansen，Peter J.
影响因子：
2.5
作者：
Kannampuzha-Francis, Jasmine;Denicol, Anna C.;Hansen, Peter J.
通讯作者：
Hansen, Peter J.
影响因子：
4.8
作者：
Loureiro, Barbara;Bonilla, Luciano;Hansen, Peter J.
通讯作者：
Hansen, Peter J.
影响因子：
6.1
作者：
Cikos, Stefan;Fabian, Dusan;Koppel, Juraj
通讯作者：
Koppel, Juraj
影响因子：
2.8
作者：
Block, J.;Bonilla, L.;Hansen, P. J.
通讯作者：
Hansen, P. J.