Associations of early childhood manganese and lead coexposure with neurodevelopment.
Associations of early childhood manganese and lead coexposure with neurodevelopment.
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DOI：
10.1289/ehp.1003300
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发表时间：
2012-01
影响因子：
10.4
通讯作者：
Téllez-Rojo MM
中科院分区：
文献类型：
--
作者：
Claus Henn B;Schnaas L;Ettinger AS;Schwartz J;Lamadrid-Figueroa H;Hernández-Avila M;Amarasiriwardena C;Hu H;Bellinger DC;Wright RO;Téllez-Rojo MM
背景资料：大多数毒理学研究都集中在单一药剂上，尽管这并不能反映人类暴露于多种化学物质的真实情况。目的：我们前瞻性地研究了儿童早期的锰-铅相互作用，以检查锰-铅共暴露是否与神经发育缺陷相关，这些缺陷比单独暴露于每种金属的影响更严重。研究方法：455名儿童在出生时参加了在墨西哥城进行的纵向队列研究，提供血液样本，并随访至36个月大。我们测量了12个月和24个月时的铅和锰，并使用Bayley婴儿发育量表II评估了12至36个月龄的6个月间隔的神经发育。结果如下：12个月和24个月时锰的平均（± SD）血液浓度分别为24.7 ± 5.9 μg/L和21.5 ± 7.4 μg/L，铅的平均（± SD）血液浓度分别为5.1 ± 2.6 μg/dL和5.0 ± 2.9 μg/dL。混合效应模型（包括5个时间点的Bayley评分）显示了随时间的显著交互作用：最高锰五分位数×连续铅;智力发育评分，β = -1.27（95%置信区间（CI）：-2.18，-0.37）;精神发育评分，β = -0.92（95% CI：-1.76，-0.09）。高锰儿童12个月铅对18个月智力发育和24- 36个月智力发育评分的影响斜率比中等锰水平儿童更陡。结论：我们观察到的证据之间的协同作用，铅和锰，从而铅毒性增加儿童高锰共同暴露。研究结果强调了了解混合暴露对健康影响的重要性，特别是在儿童早期等潜在敏感的发育阶段。
Background: Most toxicologic studies focus on a single agent, although this does not reflect real-world scenarios in which humans are exposed to multiple chemicals. Objectives: We prospectively studied manganese–lead interactions in early childhood to examine whether manganese–lead coexposure is associated with neurodevelopmental deficiencies that are more severe than expected based on effects of exposure to each metal alone. Methods: Four hundred fifty-five children were enrolled at birth in an longitudinal cohort study in Mexico City, provided blood samples, and were followed until 36 months of age. We measured lead and manganese at 12 and 24 months and assessed neurodevelopment at 6-month intervals from 12 to 36 months of age using Bayley Scales of Infant Development–II. Results: Mean (± SD) blood concentrations at 12 and 24 months were, respectively, 24.7 ± 5.9 μg/L and 21.5 ± 7.4 μg/L for manganese and 5.1 ± 2.6 μg/dL and 5.0 ± 2.9 μg/dL for lead. Mixed-effects models, including Bayley scores at five time points, showed a significant interaction over time: highest manganese quintile × continuous lead; mental development score, β = –1.27 [95% confidence interval (CI): –2.18, –0.37]; psychomotor development score, β = –0.92 (95% CI: –1.76, –0.09). Slopes for the estimated 12-month lead effect on 18-month mental development and 24- through 36-month psychomotor development scores were steeper for children with high manganese than for children with midrange manganese levels. Conclusions: We observed evidence of synergism between lead and manganese, whereby lead toxicity was increased among children with high manganese coexposure. Findings highlight the importance of understanding health effects of mixed exposures, particularly during potentially sensitive developmental stages such as early childhood.
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影响因子：
9.8
作者：
Aelion, C. Marjorie;Davis, Harley T.;McDermott, Suzanne;Lawson, Andrew B.
通讯作者：
Lawson, Andrew B.
影响因子：
8
作者：
Gomaa, A;Hu, H;Hernandez-Avila, M
通讯作者：
Hernandez-Avila, M
影响因子：
3.6
作者：
CHAN, AWK;MINSKI, MJ;LAI, JCK
通讯作者：
LAI, JCK
影响因子：
158.5
作者：
Canfield, RL;Henderson, CR;Lanphear, BP
通讯作者：
Lanphear, BP
影响因子：
10.4
作者：
Bouchard MF;Sauvé S;Barbeau B;Legrand M;Brodeur MÈ;Bouffard T;Limoges E;Bellinger DC;Mergler D
通讯作者：
Mergler D