A bioinspired, passive microfluidic lobe filtration system.
A bioinspired, passive microfluidic lobe filtration system.
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DOI：
10.1039/d1lc00449b
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发表时间：
2021-09-28
期刊：
影响因子：
6.1
通讯作者：
San-Miguel A
中科院分区：
文献类型：
--
作者：
Clark AS;San-Miguel A
微粒过滤在许多医学和生物应用中起着重要作用。基于尺寸的微流体过滤系统可能受到堵塞的影响，这妨碍了它们在高通量和连续应用中的使用。为了解决这些问题，我们已经开发了两个微流体叶片过滤器生物启发的过滤机制的两个物种的曼塔射线。这些芯片通过使用两个等间距的过滤器瓣阵列，实现了对10 - 30 μm颗粒的精确控制和高通量过滤。对于每种过滤器设计，我们研究了多个入口流速和颗粒尺寸，以确定成功的操作参数。过滤效率随流体流速增加而增加，表明颗粒惯性效应在波瓣过滤器分离中起关键作用。微粒过滤效率高达99%，可获得20毫升/分钟的入口流速。每个过滤器设计成功地增加了微粒浓度的两个或更多的因素，在不同的入口流速范围从6-16毫升/分钟。在较高的入口流速，ANSYS Fluent模拟每个设备揭示了一个复杂的速度分布，包含三个局部最大值和两个拐点。最终，我们表明，从波瓣阵列到最近的局部最大值和速度曲线的拐点的距离可以用于成功地估计在每个操作流速下的波瓣过滤效率。Lobe过滤是一种生物启发、非堵塞的微粒过滤机制，能够进行高通量处理。复杂的速度分布的模拟提供了一个强大的解释，这种微粒过滤机制。
Microparticle filtration plays an important role in many medical and biological applications. Size-based microfluidic filtration systems can be affected by clogging, which prevents their use in high-throughput and continuous applications. To address these concerns, we have developed two microfluidic lobe filters bioinspired by the filtration mechanism of two species of Manta Ray. These chips enable filtration of particles around 10 - 30 μm with precise control and high throughput by using two arrays of equally spaced filter lobes. For each filter design, we investigated multiple inlet flow rates and particle sizes to identify successful operational parameters. Filtration efficiency increases with fluid flow rate, suggesting that particle inertial effects play a key role in lobe filter separation. Microparticle filtration efficiencies up to 99% were obtainable with inlet flow rates of 20 mL/min. Each filter design successfully increased microparticle concentrations by a factor of two or greater at different inlet flow rates ranging from 6-16 mL/min. At higher inlet flow rates, ANSYS Fluent simulations of each device revealed a complex velocity profile that contains three local maxima and two inflection points. Ultimately, we show that distances from the lobe array to the closest local maxima and inflection point of the velocity profile can be used to successfully estimate lobe filtration efficiency at each operational flow rate. Lobe filtration is a bioinspired, non-clogging microparticle filtration mechanism capable of high throughput processing. Simulations of complex velocity profiles provide a robust explanation for this microparticle filtration mechanism.
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DOI：
10.1073/pnas.1413325111
发表时间：
2014-09-09
影响因子：
11.1
作者：
Ding, Xiaoyun;Peng, Zhangli;Huang, Tony Jun
通讯作者：
Huang, Tony Jun
影响因子：
56.9
作者：
Huang, LR;Cox, EC;Sturm, JC
通讯作者：
Sturm, JC
影响因子：
2.8
作者：
Clime, Liviu;Hoa, Xuyen D.;Veres, Teodor
通讯作者：
Veres, Teodor
影响因子：
3.4
作者：
Hou, Han Wei;Bhagat, Ali Asgar S.;Lim, Chwee Teck
通讯作者：
Lim, Chwee Teck
影响因子：
3.7
作者：
Asmolov, ES
通讯作者：
Asmolov, ES