Highly host-linked viromes in the built environment possess habitat-dependent diversity and functions for potential virus-host coevolution.
Highly host-linked viromes in the built environment possess habitat-dependent diversity and functions for potential virus-host coevolution.
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DOI：
10.1038/s41467-023-38400-0
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发表时间：
2023-05-09
影响因子：
16.6
通讯作者：
Lee, Patrick K. H.
中科院分区：
文献类型：
--
作者：
Du, Shicong;Tong, Xinzhao;Lai, Alvin C. K.;Chan, Chak K.;Mason, Christopher E.;Lee, Patrick K. H.
建筑环境中的病毒(BES)引起了公共卫生问题，但对它们的研究通常比细菌少。为了更好地了解BES中的病毒动态，这项研究评估了来自四种类型BES的11个栖息地的病毒，这些BES的占有率从低到高。病毒体的多样性、组成、代谢功能和生活方式都与栖息地有关。尾状病毒属物种在北冰洋表层生境中随处可见，其中一些物种与其他环境中的物种不同。在居住者经常接触的表面上的病毒和居住在居住者皮肤上的病毒中发现了抗菌素耐药性基因。在细菌宿主和病毒中分别发现了不同的CRISPR/Cas免疫系统和抗CRISPR蛋白，这与强耦合的病毒-宿主联系一致。通过一种独特的基因插入，确定了病毒可能以特定栖息地的方式帮助宿主适应的证据。这项工作表明，病毒与宿主的相互作用在BES中频繁发生，病毒是BE微生物群中不可或缺的成员。建筑环境中的病毒引发了公众健康问题。通过分析不同的样本，Du等人。提供证据，证明病毒与宿主的相互作用经常发生在建筑环境中，并且病毒是建筑环境微生物群落的组成部分。
Viruses in built environments (BEs) raise public health concerns, yet they are generally less studied than bacteria. To better understand viral dynamics in BEs, this study assesses viromes from 11 habitats across four types of BEs with low to high occupancy. The diversity, composition, metabolic functions, and lifestyles of the viromes are found to be habitat dependent. Caudoviricetes species are ubiquitous on surface habitats in the BEs, and some of them are distinct from those present in other environments. Antimicrobial resistance genes are identified in viruses inhabiting surfaces frequently touched by occupants and in viruses inhabiting occupants’ skin. Diverse CRISPR/Cas immunity systems and anti-CRISPR proteins are found in bacterial hosts and viruses, respectively, consistent with the strongly coupled virus–host links. Evidence of viruses potentially aiding host adaptation in a specific-habitat manner is identified through a unique gene insertion. This work illustrates that virus–host interactions occur frequently in BEs and that viruses are integral members of BE microbiomes. Viruses in built environments raise public health concerns. By analyzing diverse samples, Du et al. provide evidence that virus–host interactions occur frequently in built environments and that viruses are integral members of built environment microbiomes.
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影响因子：
4.5
作者：
Callanan J;Stockdale SR;Shkoporov A;Draper LA;Ross RP;Hill C
通讯作者：
Hill C
影响因子：
5.9
作者：
Coclet, Clement;Roux, Simon
通讯作者：
Roux, Simon
影响因子：
10.7
作者：
Bobay LM;Rocha EP;Touchon M
通讯作者：
Touchon M
影响因子：
64.5
作者：
Danko D;Bezdan D;Afshin EE;Ahsanuddin S;Bhattacharya C;Butler DJ;Chng KR;Donnellan D;Hecht J;Jackson K;Kuchin K;Karasikov M;Lyons A;Mak L;Meleshko D;Mustafa H;Mutai B;Neches RY;Ng A;Nikolayeva O;Nikolayeva T;Png E;Ryon KA;Sanchez JL;Shaaban H;Sierra MA;Thomas D;Young B;Abudayyeh OO;Alicea J;Bhattacharyya M;Blekhman R;Castro-Nallar E;Cañas AM;Chatziefthimiou AD;Crawford RW;De Filippis F;Deng Y;Desnues C;Dias-Neto E;Dybwad M;Elhaik E;Ercolini D;Frolova A;Gankin D;Gootenberg JS;Graf AB;Green DC;Hajirasouliha I;Hastings JJA;Hernandez M;Iraola G;Jang S;Kahles A;Kelly FJ;Knights K;Kyrpides NC;Łabaj PP;Lee PKH;Leung MHY;Ljungdahl PO;Mason-Buck G;McGrath K;Meydan C;Mongodin EF;Moraes MO;Nagarajan N;Nieto-Caballero M;Noushmehr H;Oliveira M;Ossowski S;Osuolale OO;Özcan O;Paez-Espino D;Rascovan N;Richard H;Rätsch G;Schriml LM;Semmler T;Sezerman OU;Shi L;Shi T;Siam R;Song LH;Suzuki H;Court DS;Tighe SW;Tong X;Udekwu KI;Ugalde JA;Valentine B;Vassilev DI;Vayndorf EM;Velavan TP;Wu J;Zambrano MM;Zhu J;Zhu S;Mason CE;International MetaSUB Consortium
通讯作者：
International MetaSUB Consortium
DOI：
10.1093/bioinformatics/btp348
发表时间：
2009-08-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Capella-Gutiérrez S;Silla-Martínez JM;Gabaldón T
通讯作者：
Gabaldón T