Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode.
Treatment of breast cancer through the application of irreversible electroporation using a novel minimally invasive single needle electrode.
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DOI：
10.1007/s10549-010-0803-5
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发表时间：
2010-08
影响因子：
3.8
通讯作者：
Davalos, Rafael V.
中科院分区：
文献类型：
--
作者：
Neal, Robert E., II;Singh, Ravi;Hatcher, Heather C.;Kock, Nancy D.;Torti, Suzy V.;Davalos, Rafael V.
关键词：
不可逆电穿孔（IRE）是一种用于消融软组织的治疗技术，使用电极在细胞膜上传递强烈但短的电脉冲，产生导致细胞死亡的纳米孔。这种现象只影响细胞膜，使细胞外基质和敏感结构保持完整，使其成为治疗许多类型肿瘤的有前途的技术。在本文中，我们提出了第一个体内研究，以实现肿瘤消退，使用可平移的，临床相关的单针电极治疗管理。所用方案的电场分布的数值模型表明，1000 V/cm的场阈值足以治疗肿瘤，并且如果将相同的方案用于人类乳房内的肿瘤深处，则电场分布将略微降低。原位植入雌性Nu/Nu小鼠的7个MDA-MB 231人乳腺肿瘤中有5个观察到肿瘤消退，对照组继续生长。
Irreversible electroporation (IRE) is a therapeutic technology for the ablation of soft tissues using electrodes to deliver intense but short electric pulses across a cell membrane, creating nanopores that lead to cell death. This phenomenon only affects the cell membrane, leaving the extracellular matrix and sensitive structures intact, making it a promising technique for the treatment many types of tumors. In this paper, we present the first in vivo study to achieve tumor regression using a translatable, clinically relevant single needle electrode for treatment administration. Numerical models of the electric field distribution for the protocol used suggest that a 1000 V/cm field threshold is sufficient to treat a tumor, and that the electric field distribution will slightly decrease if the same protocol were used on a tumor deep seated within a human breast. Tumor regression was observed in 5 out of 7 MDA-MB231 human mammary tumors orthotopically implanted in female Nu/Nu mice, with continued growth in controls.
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影响因子：
158.5
作者：
FISHER, B;REDMOND, C;SIDOROVICH, L
通讯作者：
SIDOROVICH, L
影响因子：
9
作者：
Fitzal, Florian;Mittlboeck, Martina;Gnant, Michael
通讯作者：
Gnant, Michael
影响因子：
3.7
作者：
Al-Sakere B;André F;Bernat C;Connault E;Opolon P;Davalos RV;Rubinsky B;Mir LM
通讯作者：
Mir LM
影响因子：
2.9
作者：
Littrup, Peter J.;Jallad, Bassel;Chandiwala-Mody, Priti;D'Agostini, Monica;Adam, Barbara A.;Bouwman, David
通讯作者：
Bouwman, David
影响因子：
4.6
作者：
Edd, Jon F.;Horowitz, Liana;Rubinsky, Boris
通讯作者：
Rubinsky, Boris