Associations of metals and neurodevelopment: a review of recent evidence on susceptibility factors.
Associations of metals and neurodevelopment: a review of recent evidence on susceptibility factors.
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DOI：
10.1007/s40471-020-00249-y
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发表时间：
2020-12
影响因子：
3.3
通讯作者：
Henn BC
中科院分区：
文献类型：
--
作者：
Bauer JA;Fruh V;Howe CG;White RF;Henn BC
流行病学证据表明，许多金属与幼儿的不良神经行为影响有关，包括铅（Pb）、甲基汞（meHg）、锰（Mn）和砷（As）。重要的是，化学损伤可以根据宿主因素和暴露环境而变化。本系统综述总结了最近的文献调查金属和神经发育之间的关联的修改因素，包括不变的性状（性别或遗传学）或暴露条件（时间或共同暴露）。在本综述中纳入的53项研究中，调查暴露效应改变的研究数量为：30项针对性别，21项针对共同暴露，12项针对暴露时间，6项针对遗传修饰剂。金属-神经行为相关性的性别特异性效应对于所有金属都是不确定的，可能是由于评估的结果域和测量的暴露时间点的异质性。7项研究使用乳牙或其他生物标志物评价了性别和暴露时间作为修正因素，并重复测量以表征金属暴露随时间的变化。只有五项研究使用混合物的统计方法来评估两种以上金属与神经行为领域的关联。尽管对金属暴露对神经发育影响的易感性的研究有所扩大，但仍存在相当大的差距。这项工作仍然至关重要，因为确定易感亚群的特征有助于确定生物机制，对保护公众健康至关重要。
Epidemiologic evidence exists that many metals are associated with adverse neurobehavioral effects in young children, including lead (Pb), methylmercury (meHg), manganese (Mn) and arsenic (As). Importantly, chemical insult can vary depending on host factors and exposure circumstance. This systematic review summarizes the recent literature investigating modifying factors of the associations between metals and neurodevelopment, including immutable traits (sex or genetics) or exposure conditions (timing or co-exposures). Of the 53 studies included in this review, the number investigating modification of exposure effects were: 30 for sex, 21 for co-exposures, 12 for timing of exposure, and six for genetic modifiers. Sex-specific effects of metal-neurobehavioral associations were inconclusive for all metals, likely due to the heterogeneity of outcome domains assessed and the exposure time points measured. Seven studies evaluated both sex and exposure timing as modifying factors using deciduous teeth or other biomarkers with repeated measures to characterize metals exposure over time. Only five studies used statistical methods for mixtures to evaluate associations of more than two metals with neurobehavioral domains. Despite the expansion of research on susceptibility to the neurodevelopmental effects of metals exposure, considerable gaps remain. This work remains critical, as characterizing susceptible subpopulations can aid in identifying biological mechanisms and is fundamental for the protection of public health.
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影响因子：
48
作者：
Grandjean, Philippe;Landrigan, Philip J.
通讯作者：
Landrigan, Philip J.
影响因子：
11.8
作者：
Engstrom, Karin;Love, Tanzy M.;Broberg, Karin
通讯作者：
Broberg, Karin
DOI：
10.1186/s12940-016-0174-4
发表时间：
2016-08-30
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Coetzee DJ;McGovern PM;Rao R;Harnack LJ;Georgieff MK;Stepanov I
通讯作者：
Stepanov I
影响因子：
3.4
作者：
de Carvalho, Chrissie Ferreira;Oulhote, Youssef;Abreu, Neander
通讯作者：
Abreu, Neander
影响因子：
3.4
作者：
Bouchard, Maryse F.;Surette, Celine;Foucher, Delphine
通讯作者：
Foucher, Delphine