Emerging Roles of FTO in Neuropsychiatric Disorders.
Emerging Roles of FTO in Neuropsychiatric Disorders.
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DOI：
10.1155/2022/2677312
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发表时间：
2022
影响因子：
--
通讯作者：
Tan, Sijie
中科院分区：
文献类型：
--
作者：
Chang, Rui;Huang, Zeyi;Zhao, Size;Zou, Ju;Li, Yukun;Tan, Sijie
FTO（fat mass and obesity associated）是近年来发现的一种与肥胖相关的基因，在人体的多种组织中均有表达，尤其在脑组织中表达量较高。早期的研究发现，FTO参与了几个生物过程，包括大脑发育和功能。特别是，最近的研究发现FTO是N6-甲基腺苷（m6 A）的脱甲基酶，并且它可以通过mRNA的m6 A修饰来影响神经功能。目前，大量研究表明FTO与多种神经精神疾病有关。本文综述了FTO的发现、结构、功能及组织表达，并讨论了FTO与神经精神疾病的关系。此外，FTO基因通过调节多巴胺相关基因m6 A修饰在药物成瘾、重性抑郁症（MDD）和精神分裂症（SCZ）中的潜在作用也被强调。
FTO (fat mass and obesity associated) is a recently discovered gene related to obesity and expressed in various tissues of the human body, especially with high expression in the brain. Earlier studies have found that FTO is involved in several biological processes, including brain development and function. In particular, recent studies have found that FTO is a demethylase of N6-methyladenosine (m6A) and it can affect neurological function through the m6A modification of mRNA. At present, a number of studies have shown that FTO is associated with many neuropsychiatric disorders. This paper reviews the discovery, structure, function, and tissue expression of FTO followed by discussing the relationship between FTO and neuropsychiatric diseases. In addition, the potential roles of FTO gene in drug addiction, major depression (MDD), and schizophrenia (SCZ) through regulating m6A modification of dopamine related genes were also highlighted.
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