Aberrant prefrontal cortical-striatal functional connectivity in children with primary complex motor stereotypies.
Aberrant prefrontal cortical-striatal functional connectivity in children with primary complex motor stereotypies.
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DOI：
10.1016/j.cortex.2021.05.022
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Singer HS
中科院分区：
文献类型：
--
作者：
Augustine F;Nebel MB;Mostofsky SH;Mahone EM;Singer HS
运动刻板印象是有节奏的、重复的、持续的、可预测的、无障碍的运动，会随着分心而停止。虽然一度认为仅发生在患有神经发育障碍（如自闭症）的儿童中，但复杂运动刻板（CMS）在其他典型发育儿童（原发性CMS）中的存在和持续性已经得到了很好的证实。然而，很少有人知道这些不必要的行动的基础病理生理学。本研究的目的是使用静息态功能磁共振成像，以评估功能连接额纹状体电路，是必不可少的目标导向和习惯性活动的儿童与初级复杂的运动刻板印象。前额叶皮层和纹状体区域之间的功能连接，被认为是必不可少的发展目标导向的行为，是减少与他们的典型发展同龄人相比，在儿童与原发性CMS。相比之下，运动/运动前区和纹状体区域之间的功能连接，发展和调节习惯性行为的关键，没有组之间的差异。这种记录在案的前额叶纹状体连接的改变可能提供了潜在的机制，在其他发育正常的儿童复杂的运动刻板印象的存在和持久性。
Motor stereotypies are rhythmic, repetitive, prolonged, predictable, and purposeless movements that stop with distraction. Although once believed to occur only in children with neurodevelopmental disorders such as autism, the presence and persistence of complex motor stereotypies (CMS) in otherwise typically developing children (primary CMS) has been well-established. Little, however, is known about the underlying pathophysiology of these unwanted actions. The aim of the present study was to use resting-state functional magnetic resonance imaging to evaluate functional connectivity within frontal-striatal circuits that are essential for goal-directed and habitual activity in children with primary complex motor stereotypies. Functional connectivity between prefrontal cortical and striatal regions, considered essential for developing goal-directed behaviors, was reduced in children with primary CMS compared to their typically developing peers. In contrast, functional connectivity between motor/premotor and striatal regions, critical for developing and regulating habitual behaviors, did not differ between groups. This documented alteration of prefrontal to striatal connectivity could provide the underlying mechanism for the presence and persistence of complex motor stereotypies in otherwise developmentally normal children.
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