Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in Apc(Min/+) mice.
Response to 5-fluorouracil chemotherapy is modified by dietary folic acid deficiency in Apc(Min/+) mice.
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Apc(Min/ ) 小鼠中膳食叶酸缺乏会改变对 5-氟尿嘧啶化疗的反应。
DOI：
10.1016/s0304-3835(02)00402-0
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发表时间：
2002
期刊：
影响因子：
9.7
通讯作者：
Berger,FranklinG
中科院分区：
文献类型：
--
作者：
Tucker,JodyM;Davis,Celestia;Kitchens,MariaE;Bunni,MarleneA;Priest,DavidG;Spencer,HTrent;Berger,FranklinG
5-Fluorouracil (5-FU) has been the foundation of advanced colorectal cancer treatment for over 40 years. The ApcMin/+mouse, which is genetically predisposed to intestinal neoplasia, was used to examine the effects of 5-FU in this system and the impact of dietary folic acid on those effects. 5-FU treatment resulted in a 60–80% reduction in tumor number. Clinically relevant toxicities, including myelosuppression and mucositis, are a part of this response. Tumor numbers rebounded completely following termination of 5-FU therapy, indicating that the drug inhibits tumor growth but does not eradicate them. In mice that were fed with a defined diet containing no folic acid (0ppm), 5-FU not only induced regression of pre-existing tumors, but also inhibited tumor recovery following drug withdrawal. Our data indicate that a dietary folic acid deficiency, in promoting tumor regression and inhibiting tumor recovery, may enhance the therapeutic effects of 5-FU.
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前信使 RNA 与 5-氟尿苷处理细胞提取物的体外剪接。
DOI：
10.1042/bj2970297
发表时间：
1994
期刊：
The Biochemical journal
影响因子：
--
作者：
J. R. Patton
通讯作者：
J. R. Patton
影响因子：
6.4
作者：
Goemans, Anouk;Viding, Essi;McCrory, Eamon
通讯作者：
McCrory, Eamon
影响因子：
56.9
作者：
MOSER, AR;PITOT, HC;DOVE, WF
通讯作者：
DOVE, WF
5-氟、5-氯和 5-溴尿苷抑制前 mRNA 剪接。
DOI：
--
发表时间：
1989
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Sierakowska,H;Shukla,RR;Dominski,Z;Kole,R
通讯作者：
Kole,R
将 5-氟尿嘧啶掺入 U2 和 U6 snRNA 中可抑制 mRNA 前体剪接。
DOI：
--
发表时间：
1994
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Lenz,HJ;Manno,DJ;Danenberg,KD;Danenberg,PV
通讯作者：
Danenberg,PV