Obligatory role for the immediate early gene NARP in critical period plasticity.
Obligatory role for the immediate early gene NARP in critical period plasticity.
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DOI：
10.1016/j.neuron.2013.05.016
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发表时间：
2013-07-24
期刊：
影响因子：
16.2
通讯作者：
Quinlan EM
中科院分区：
文献类型：
--
作者：
Gu Y;Huang S;Chang MC;Worley P;Kirkwood A;Quinlan EM
The immediate early gene NARP is an AMPAR binding protein that is specifically enriched at excitatory synapses onto fast-spiking parvalbumin-positive interneurons (FS (PV) INs). Here we show that transgenic deletion of NARP decreases the number of excitatory synaptic inputs onto FS (PV) INs, and reduces net excitatory synaptic drive onto FS (PV) INs. Accordingly, the visual cortex NARP −/− mice is hyper-excitable, and unable to express ocular dominance plasticity, although many aspects of visual function are unimpaired. Importantly, the number and strength of inhibitory synaptic contacts from FS (PV) INs onto principle neurons in the visual cortex is normal in NARP −/− mice, and enhancement of this output recovers the expression of experience-dependent synaptic plasticity. Thus the recruitment of inhibition from FS (PV) INs plays a central role in enabling the critical period for ocular dominance plasticity.
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