γ and the coordination of spiking activity in early visual cortex.

γ and the coordination of spiking activity in early visual cortex.
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γ 和早期视觉皮层尖峰活动的协调。

DOI:
10.1016/j.neuron.2012.12.036
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发表时间:
2013-02-20
期刊:
影响因子:
16.2
通讯作者:
Kohn A
Kohn A
中科院分区:
医学1区
文献类型:
--
作者:
Jia X;Tanabe S;Kohn A

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在认知和知觉过程中,局部场势(LFP)的伽马分量会升高。已有研究表明,伽玛功率反映了神经元群体同步性的强弱,从而影响了大脑皮层区域之间的信号传递。然而,协调的尖峰活动和伽马之间的关系仍然不清楚,而且对皮质信号的影响在很大程度上还没有得到测试。我们通过记录麻醉猕猴V1和V2区的神经元群体来研究这些问题。我们发现,诱导强烈、连贯的伽马节律的视觉刺激会导致增强的成对和更高阶的V1同步。这与V1-V2刺激性活动的更强耦合有关,以视网膜定位的方式。耦合与V1放电的伽马调制的关系比与下游V2节律的关系更强。因此,我们的结果表明,伽马功率的增加与皮层区域内和皮层之间的刺激性活动的更强的协调有关。
Gamma components of the local field potential (LFP) are elevated during cognitive and perceptual processes. It has been suggested that gamma power indicates the strength of neuronal population synchrony, which influences the relaying of signals between cortical areas. However, the relationship between coordinated spiking activity and gamma remains unclear, and the influence on corticocortical signaling largely untested. We investigated these issues by recording from neuronal populations in areas V1 and V2 of anesthetized macaque monkeys. We found that visual stimuli that induce a strong, coherent gamma rhythm result in enhanced pairwise and higher-order V1 synchrony. This is associated with stronger coupling of V1-V2 spiking activity, in a retinotopically specific manner. Coupling is more strongly related to the gamma modulation of V1 firing than to the downstream V2 rhythm. Our results thus show that elevated gamma power is associated with stronger coordination of spiking activity both within and between cortical areas.
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