High-resolution fMRI reveals match enhancement and attentional modulation in the human medial temporal lobe.
High-resolution fMRI reveals match enhancement and attentional modulation in the human medial temporal lobe.
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DOI：
10.1162/jocn.2010.21509
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发表时间：
2011-03
影响因子：
3.2
通讯作者：
Wagner AD
中科院分区：
文献类型：
--
作者：
Dudukovic NM;Preston AR;Archie JJ;Glover GH;Wagner AD
内侧颞叶（MTL）的主要功能是发出先前遇到行为相关刺激的信号。MTL匹配增强-增加激活时，查看以前遇到的刺激-已被观察到的目标相关的刺激在非人类灵长类动物在延迟匹配样本任务和人类在更复杂的关系记忆任务。匹配增强可以替代地反映（a）相对于新颖刺激对熟悉的注意力响应，或者（B）对围绕过去遇到熟悉刺激的上下文细节的检索。为了利用海马体中匹配增强的功能意义，进行了人类MTL的高分辨率功能磁共振成像，而参与者出席，忽略，或被动地观看面部和场景刺激的修改后的延迟匹配到样本任务的背景下。在每次“关注”试验中，在与其中一个关注刺激匹配或不匹配的探测之前遇到两个目标相关刺激，从而能够检查遇到其中一个目标相关刺激作为匹配探测的后果。对其他（未探测的）目标相关刺激的后期记忆。fMRI显示，海马对注意操作不敏感，海马旁皮层受场景定向注意的调节，而嗅周皮层则表现出更为细微和普遍的注意效应。相比之下，所有海马子字段表现出匹配增强的探针，和postscan测试显示更准确的识别记忆的nonprobed目标相关的刺激匹配相对于不匹配的试验。这些数据表明，匹配增强人类海马反映了检索的其他目标相关的上下文细节周围的刺激的前一次遭遇。
A primary function of the medial temporal lobe (MTL) is to signal prior encounter with behaviorally relevant stimuli. MTL match enhancement—increased activation when viewing previously encountered stimuli—has been observed for goal-relevant stimuli in nonhuman primates during delayed-match-to-sample tasks and in humans during more complex relational memory tasks. Match enhancement may alternatively reflect (a) an attentional response to familiar relative to novel stimuli or (b) the retrieval of contextual details surrounding the past encounter with familiar stimuli. To gain leverage on the functional significance of match enhancement in the hippocampus, high-resolution fMRI of human MTL was conducted while participants attended, ignored, or passively viewed face and scene stimuli in the context of a modified delayed-match-to-sample task. On each “attended” trial, two goal-relevant stimuli were encountered before a probe that either matched or mismatched one of the attended stimuli, enabling examination of the consequences of encountering one of the goal-relevant stimuli as a match probe on later memory for the other (nonprobed) goal-relevant stimulus. fMRI revealed that the hippocampus was insensitive to the attentional manipulation, whereas parahippocampal cortex was modulated by scene-directed attention, and perirhinal cortex showed more subtle and general effects of attention. By contrast, all hippocampal subfields demonstrated match enhancement to the probe, and a postscan test revealed more accurate recognition memory for the nonprobed goal-relevant stimulus on match relative to mismatch trials. These data suggest that match enhancement in human hippocampus reflects retrieval of other goal-relevant contextual details surrounding a stimulusʼs prior encounter.
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影响因子：
64.8
作者：
Epstein, R;Kanwisher, N
通讯作者：
Kanwisher, N
影响因子：
25
作者：
Eldridge, LL;Knowlton, BT;Engel, SA
通讯作者：
Engel, SA
影响因子：
5.3
作者：
Duncan, Katherine;Curtis, Clayton;Davachi, Lila
通讯作者：
Davachi, Lila
影响因子：
3.5
作者：
Brozinsky, CJ;Yonelinas, AP;Ranganath, C
通讯作者：
Ranganath, C
使用高分辨率功能磁共振成像对人类内侧颞叶进行成像。
影响因子：
16.2
作者：
Carr, Valerie A.;Rissman, Jesse;Wagner, Anthony D.
通讯作者：
Wagner, Anthony D.