Gut-on-a-chip for disease models.
Gut-on-a-chip for disease models.
复制标题
DOI：
10.1177/20417314221149882
复制
发表时间：
2023-01
影响因子：
8.2
通讯作者：
Li, Xiang-Guang
中科院分区：
文献类型：
--
作者：
Xian, Changxiu;Zhang, Jiaxin;Zhao, Suqing;Li, Xiang-Guang
肠道是人体内负责消化和吸收的重要器官，在病原体入侵中起着至关重要的作用。与其他传统模型相比，gut-on-a-chip具有许多独特的优点，因此，它可以被认为是研究肠道功能和疾病的一种新模型。基于芯片设计，我们可以复制肠道的体内微环境，并研究个体变量对实验的影响。近年来，它已被用于研究多种疾病。为了更好地模拟肠道微环境，肠道芯片的结构和功能不断优化和改进。由于疾病机制的复杂性，芯片上的肠道可以与其他器官芯片结合使用。本文综述了人体肠道的结构和功能以及肠道芯片的发展和改进。最后，我们提出并讨论了肠道芯片在炎症性肠病（IBD），病毒感染和苯丙酮尿症中的应用。进一步提高芯片上肠的模拟性和高通量以及实现个性化治疗是芯片上肠作为疾病模型应该解决的问题。
The intestinal tract is a vital organ responsible for digestion and absorption in the human body and plays an essential role in pathogen invasion. Compared with other traditional models, gut-on-a-chip has many unique advantages, and thereby, it can be considered as a novel model for studying intestinal functions and diseases. Based on the chip design, we can replicate the in vivo microenvironment of the intestine and study the effects of individual variables on the experiment. In recent years, it has been used to study several diseases. To better mimic the intestinal microenvironment, the structure and function of gut-on-a-chip are constantly optimised and improved. Owing to the complexity of the disease mechanism, gut-on-a-chip can be used in conjunction with other organ chips. In this review, we summarise the human intestinal structure and function as well as the development and improvement of gut-on-a-chip. Finally, we present and discuss gut-on-a-chip applications in inflammatory bowel disease (IBD), viral infections and phenylketonuria. Further improvement of the simulation and high throughput of gut-on-a-chip and realisation of personalised treatments are the problems that should be solved for gut-on-a-chip as a disease model.
登录
查看更多内容
DOI：
10.3390/pathogens10030256
发表时间：
2021-02-24
期刊：
Pathogens (Basel, Switzerland)
影响因子：
--
作者：
Donia A;Hassan SU;Zhang X;Al-Madboly L;Bokhari H
通讯作者：
Bokhari H
影响因子：
5.2
作者：
Anjum M;Laitila A;Ouwehand AC;Forssten SD
通讯作者：
Forssten SD
影响因子：
7.4
作者：
Fusco, Federica;Perottoni, Simone;Giordano, Carmen;Riva, Antonella;Iannone, Luigi Francesco;De Caro, Carmen;Russo, Emilio;Albani, Diego;Striano, Pasquale
通讯作者：
Striano, Pasquale
影响因子：
5.6
作者：
Bein A;Kim S;Goyal G;Cao W;Fadel C;Naziripour A;Sharma S;Swenor B;LoGrande N;Nurani A;Miao VN;Navia AW;Ziegler CGK;Montañes JO;Prabhala P;Kim MS;Prantil-Baun R;Rodas M;Jiang A;O'Sullivan L;Tillya G;Shalek AK;Ingber DE
通讯作者：
Ingber DE
DOI：
10.1007/978-1-4939-0897-4_3
发表时间：
2014-01-01
期刊：
MICROBIAL ENDOCRINOLOGY: THE MICROBIOTA-GUT-BRAIN AXIS IN HEALTH AND DISEASE
影响因子：
--
作者：
Furness, John B.;Callaghan, Brid P.;Cho, Hyun-Jung
通讯作者：
Cho, Hyun-Jung