Altered default network resting-state functional connectivity in adolescents with Internet gaming addiction.-猫眼课题宝

DOI：

10.1371/journal.pone.0059902

发表时间：

2013

期刊：

PloS one

影响因子：

3.7

通讯作者：

中科院分区：

综合性期刊3区

文献类型：

作者：

Ding WN;Sun JH;Sun YW;Zhou Y;Li L;Xu JR;Du YS

来源链接：

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608539/?report=classic

过度使用互联网与各种负面的心理社会后果有关。这项研究使用静息态功能磁共振成像 (fMRI) 来研究患有网络游戏成瘾 (IGA) 的青少年的功能连接是否发生改变。 17 名 IGA 青少年和 24 名正常对照青少年接受了 7.3 分钟的静息态 fMRI 扫描。通过使用时间相关方法研究同步低频 fMRI 信号波动，确定所有受试者的后扣带皮层 (PCC) 连接性。为了评估 IGA 症状严重程度和 PCC 连接性之间的关系，将代表与 PCC 连接性相关区域的对比图像与 17 名 IGA 受试者的 Chen 网络成瘾量表 (CIAS) 和 Barratt 冲动量表 - 11 (BIS-11) 得分以及他们每周的互联网使用时间相关联。两组间年龄、性别、受教育年限分布无显着差异。与对照组相比，IGA 受试者每周使用互联网的时间（小时）更长（p<0.0001），CIAS（p<0.0001）和 BIS-11（p = 0.01）分数更高。与对照组相比，IGA 受试者双侧小脑后叶和颞中回的功能连接性增强。双侧顶下小叶和右颞下回的连通性降低。与 PCC 的连通性与右侧楔前叶、后扣带回、丘脑、尾状核、伏隔核、辅助运动区和舌回的 CIAS 评分呈正相关。与右小脑前叶和左顶上小叶呈负相关。我们的结果表明，患有 IGA 的青少年表现出不同的大脑活动静息态模式。由于这些改变与物质成瘾患者的改变部分一致，因此它们支持这样的假设：IGA 作为一种行为成瘾，可能与其他成瘾性疾病具有相似的神经生物学异常。

Excessive use of the Internet has been linked to a variety of negative psychosocial consequences. This study used resting-state functional magnetic resonance imaging (fMRI) to investigate whether functional connectivity is altered in adolescents with Internet gaming addiction (IGA). Seventeen adolescents with IGA and 24 normal control adolescents underwent a 7.3 minute resting-state fMRI scan. Posterior cingulate cortex (PCC) connectivity was determined in all subjects by investigating synchronized low-frequency fMRI signal fluctuations using a temporal correlation method. To assess the relationship between IGA symptom severity and PCC connectivity, contrast images representing areas correlated with PCC connectivity were correlated with the scores of the 17 subjects with IGA on the Chen Internet Addiction Scale (CIAS) and Barratt Impulsiveness Scale-11 (BIS-11) and their hours of Internet use per week. There were no significant differences in the distributions of the age, gender, and years of education between the two groups. The subjects with IGA showed longer Internet use per week (hours) (p<0.0001) and higher CIAS (p<0.0001) and BIS-11 (p = 0.01) scores than the controls. Compared with the control group, subjects with IGA exhibited increased functional connectivity in the bilateral cerebellum posterior lobe and middle temporal gyrus. The bilateral inferior parietal lobule and right inferior temporal gyrus exhibited decreased connectivity. Connectivity with the PCC was positively correlated with CIAS scores in the right precuneus, posterior cingulate gyrus, thalamus, caudate, nucleus accumbens, supplementary motor area, and lingual gyrus. It was negatively correlated with the right cerebellum anterior lobe and left superior parietal lobule. Our results suggest that adolescents with IGA exhibit different resting-state patterns of brain activity. As these alterations are partially consistent with those in patients with substance addiction, they support the hypothesis that IGA as a behavioral addiction that may share similar neurobiological abnormalities with other addictive disorders.