Neuroendocrine and immune pathways from pre- and perinatal stress to substance abuse.
Neuroendocrine and immune pathways from pre- and perinatal stress to substance abuse.
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DOI：
10.1016/j.ynstr.2018.09.004
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发表时间：
2018-11
影响因子：
5
通讯作者：
Fisher PA
中科院分区：
文献类型：
--
作者：
Horn SR;Roos LE;Berkman ET;Fisher PA
早期生活逆境是药物滥用和成瘾的一个有记录的风险因素。产前和围产期（即，从胚胎植入、怀孕到6个月大）是一个关键时期，其特点是高度的生物可塑性和脆弱性，使围产期压力成为一种特别强烈的逆境形式。神经内分泌和免疫系统是成瘾风险传递的关键机制。我们回顾动物和人类的研究，提供了围产期应激，神经内分泌和免疫失调，药物滥用和成瘾的风险之间的联系的初步证据。一个翻译神经科学的角度来阐明产前和围产期诱导的生物学机制与成瘾和讨论的影响，预防和干预工作。大量证据支持产前和围产期压力与下丘脑-垂体-肾上腺轴和免疫系统调节异常之间的关联，以及神经内分泌/免疫功能与成瘾风险之间的联系。需要开展更多的工作，明确审查产前和围产期压力与神经内分泌/免疫紊乱之间的相互作用，这些因素共同增加了药物滥用的风险。未来的工作需要充分了解产前和围产期压力如何引起生物学改变，从而使个体更容易成瘾。这种知识将加强理论驱动和实践支持的药物滥用和成瘾预防工作。
Early life adversity is a documented risk factor for substance abuse and addiction. The pre- and perinatal period (i.e., from implantation, through pregnancy, to 6 months of age) is a critical period marked by high biological plasticity and vulnerability, making perinatal stress a particularly robust form of adversity. The neuroendocrine and immune systems are key mechanisms implicated in the transmission of addiction risk. We review animal and human studies that provide preliminary evidence for links between perinatal stress, neuroendocrine and immune dysregulation, and risk for substance abuse and addiction. A translational neuroscience perspective is employed to elucidate pre- and perinatally-induced biological mechanisms linked to addiction and discuss implications for prevention and intervention efforts. Significant evidence supports associations between pre- and perinatal stress and dysregulation of the hypothalamic-pituitary-adrenal axis and immune systems as well as links between neuroendocrine/immune functioning and addiction risk. More work is needed to explicitly examine the interplay between pre- and perinatal stress and neuroendocrine/immune disruptions that together heighten substance abuse risk. Future work is needed to fully understand how pre- and perinatal stress induces biological alterations to predispose individuals to higher risk for addiction. Such knowledge will strengthen theoretically-driven and empirically-supported prevention efforts for substance abuse and addiction.
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影响因子：
2.9
作者：
Delaney-Black, Virginia;Chiodo, Lisa M.;Hannigan, John H.;Greenwald, Mark K.;Janisse, James;Patterson, Grace;Huestis, Marilyn A.;Partridge, Robert T.;Ager, Joel;Sokol, Robert J.
通讯作者：
Sokol, Robert J.
影响因子：
2.9
作者：
Conradt E;Lagasse LL;Shankaran S;Bada H;Bauer CR;Whitaker TM;Hammond JA;Lester BM
通讯作者：
Lester BM
影响因子：
4.6
作者：
Ahnert, L;Gunnar, MR;Barthel, M
通讯作者：
Barthel, M
影响因子：
4.8
作者：
Brown, RW;Diaz, R;Seckl, JR
通讯作者：
Seckl, JR
影响因子：
--
作者：
Baer, JS;Sampson, PD;Streissguth, AP
通讯作者：
Streissguth, AP