Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients.
Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients.
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DOI：
10.1016/j.bbi.2010.10.012
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发表时间：
2011-02
影响因子：
15.1
通讯作者：
Cole, Steve W.
中科院分区：
文献类型：
--
作者：
Lutgendorf, Susan K.;DeGeest, Koen;Dahmoush, Laila;Farley, Donna;Penedo, Frank;Bender, David;Goodheart, Michael;Buekers, Thomas E.;Mendez, Luis;Krueger, Gina;Clevenger, Lauren;Lubaroff, David M.;Sood, Anil K.;Cole, Steve W.
去甲肾上腺素能途径与卵巢癌的生长和进展有关。在动物癌症模型中，肿瘤内去甲肾上腺素 (NE) 已被证明会随着应激而增加，但对于卵巢癌患者中肿瘤 NE 如何随疾病阶段和生物行为因素变化的情况知之甚少。本研究调查了 68 名卵巢癌患者的术前社会支持、抑郁情绪、感知压力、焦虑、肿瘤组织学和肿瘤儿茶酚胺（NE 和肾上腺素 [E]）水平之间的关系。我们还检查了生物行为测量与肿瘤儿茶酚胺之间观察到的关联是否扩展到其他区室。晚期 (p=0.006) 和高级 (p=0.001) 肿瘤中的 NE 水平较高。调整分期、分级和围手术期 β 受体阻滞剂后，认为缺乏社会支持的患者的肿瘤 NE 显着较高（β = -0.29，p = 0.012）。社会支持和腹水 NE 也出现类似的趋势（根据阶段、围手术期 β 受体阻滞剂和咖啡因进行调整：β=−0.50，p=0.075），但血浆 NE 则不然。其他生物行为因素与肿瘤、腹水或血浆 NE 无关（p 值 > 0.21）。在大多数肿瘤中检测不到肿瘤 E，因此没有进一步分析 E。总之，这些结果表明肿瘤 NE 提供了与循环血浆浓度不同的信息。肿瘤 NE 水平升高与肿瘤分级和分期相关。低主观社会支持与瘤内 NE 升高相关。由于β-肾上腺素能信号传导与肿瘤生长的关键生物途径相关，这些发现可能对卵巢癌患者的预后产生影响。
Noradrenergic pathways have been implicated in growth and progression of ovarian cancer. Intratumoral norepinephrine (NE) has been shown to increase with stress in an animal cancer model, but little is known regarding how tumor NE varies with disease stage and with biobehavioral factors in ovarian cancer patients. This study examined relationships between pre-surgical measures of social support, depressed mood, perceived stress, anxiety, tumor histology and tumor catecholamine (NE and epinephrine [E]) levels among 68 ovarian cancer patients. We also examined whether associations observed between biobehavioral measures and tumor catecholamines extended to other compartments. Higher NE levels were found in advanced stage (p=0.006) and higher grade (p=0.001) tumors. Adjusting for stage, grade, and peri-surgical beta blockers, patients with a perceived lack of social support had significantly higher tumor NE (β = −0.29, p=0.012). A similar trend was seen for social support and ascites NE (adjusting for stage, peri-surgical beta blockers and caffeine: β=−0.50, p=0.075), but not for plasma NE. Other biobehavioral factors were not related to tumor, ascites, or plasma NE (p values > 0.21). Tumor E was undetectable in the majority of tumors and thus E was not further analyzed. In summary, these results suggest that tumor NE provides distinct information from circulating plasma concentrations. Tumor NE levels were elevated in relationship to tumor grade and stage. Low subjective social support was associated with elevated intratumoral NE. As beta-adrenergic signaling is related to key biological pathways involved in tumor growth, these findings may have implications for patient outcomes in ovarian cancer.
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影响因子：
6.2
作者：
Lutgendorf, SK;Johnsen, EL;Sood, AK
通讯作者：
Sood, AK
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
4.8
作者：
Nilsson, Monique B.;Armaiz-Pena, Guillermo;Sood, Anil K.
通讯作者：
Sood, Anil K.
影响因子：
11.2
作者：
Chakroborty D;Sarkar C;Basu B;Dasgupta PS;Basu S
通讯作者：
Basu S
影响因子：
4.7
作者：
Hughes, JW;Watkins, L;Sherwood, A
通讯作者：
Sherwood, A