Decreased reward-related brain function prospectively predicts increased substance use.
Decreased reward-related brain function prospectively predicts increased substance use.
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DOI：
10.1037/abn0000711
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发表时间：
2021-11
影响因子：
4.6
通讯作者：
Alloy LB
中科院分区：
文献类型：
--
作者：
Bart CP;Nusslock R;Ng TH;Titone MK;Carroll AL;Damme KSF;Young CB;Armstrong CC;Chein J;Alloy LB
物质使用和成瘾是突出的全球健康问题，并与奖励敏感性异常有关。奖赏敏感性和接近动机由包括眶额皮质（OFC）、腹侧纹状体（VS）和背侧纹状体（DS）的额-纹状体神经回路支持。尽管研究强调了有问题的物质使用者的奖励神经回路异常，但关于这种使用是否源于过高或过低的奖励敏感性的问题仍然存在。本研究探讨了奖励相关的脑功能是否预测随后的物质使用过程。参与者是79个右撇子（法师= 21.52，SD = 2.19年），谁完成了货币奖励延迟功能磁共振成像任务，并采取后续措施评估物质使用频率和损害。平均随访时间为9.1个月。兴趣区域分析集中在MID的奖励预期阶段。在奖励预期过程中VS的激活减少，预示着随访时物质使用频率增加。在奖励预期期间DS激活减少预测在随访时物质使用频率增加，但这一发现没有通过多重比较的校正。分析调整了相关协变量，包括基线物质使用和MRI扫描前是否存在终身物质使用障碍。结果支持奖励低敏感性理论，这表明减少奖励相关的脑功能是增加物质使用的风险因素。研究结果对理解有问题的物质使用的病理生理学有意义，并强调了额纹状体奖赏回路在成瘾发展和维持中的重要性。目前的研究结果表明，减少奖励相关的神经活动，以次要奖励赋予更大的物质使用频率的风险。这些发现支持成瘾的奖励低敏感性理论。
Substance use and addiction are prominent global health concerns and are associated with abnormalities in reward sensitivity. Reward sensitivity and approach motivation are supported by a fronto-striatal neural circuit including the orbitofrontal cortex (OFC), ventral striatum (VS), and dorsal striatum (DS). Although research highlights abnormalities in reward neural circuitry among individuals with problematic substance use, questions remain about whether such use arises from excessively high, or excessively low, reward sensitivity. This study examined whether reward-related brain function predicted subsequent substance use course. Participants were 79 right-handed individuals (Mage = 21.52, SD = 2.19 years), who completed a Monetary Incentive Delay fMRI task, and follow-up measures assessing substance use frequency and impairment. The average duration of the follow-up period was 9.1 months. Regions-of-interest analyses focused on the reward anticipation phase of the MID. Decreased activation in the VS during reward anticipation predicted increased substance use frequency at follow-up. Decreased DS activation during reward anticipation predicted increased substance use frequency at follow-up, but this finding did not pass correction for multiple comparisons. Analyses adjusted for relevant covariates, including baseline substance use and the presence or absence of a lifetime substance use disorder prior to MRI scanning. Results support the reward hyposensitivity theory, suggesting that decreased reward-related brain function is a risk factor for increased substance use. Results have implications for understanding the pathophysiology of problematic substance use and highlight the importance of the fronto-striatal reward circuit in the development and maintenance of addiction. Findings from the current study suggest that decreased reward-related neural activity to secondary rewards confers risk for greater substance use frequency. These findings support the reward hyposensitivity theory of addiction.
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影响因子：
16.6
作者：
Büchel C;Peters J;Banaschewski T;Bokde AL;Bromberg U;Conrod PJ;Flor H;Papadopoulos D;Garavan H;Gowland P;Heinz A;Walter H;Ittermann B;Mann K;Martinot JL;Paillère-Martinot ML;Nees F;Paus T;Pausova Z;Poustka L;Rietschel M;Robbins TW;Smolka MN;Gallinat J;Schumann G;Knutson B;IMAGEN consortium
通讯作者：
IMAGEN consortium
影响因子：
10.6
作者：
Balodis IM;Potenza MN
通讯作者：
Potenza MN
影响因子：
4.4
作者：
Dawe, S;Gullo, MJ;Loxton, NJ
通讯作者：
Loxton, NJ
影响因子：
6.9
作者：
Baker, Travis E.;Castellanos-Ryan, Natalie;Conrod, Patricia
通讯作者：
Conrod, Patricia
影响因子：
3.7
作者：
Forbes EE;Rodriguez EE;Musselman S;Narendran R
通讯作者：
Narendran R