Anticipatory reward processing in addicted populations: a focus on the monetary incentive delay task.
Anticipatory reward processing in addicted populations: a focus on the monetary incentive delay task.
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DOI：
10.1016/j.biopsych.2014.08.020
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发表时间：
2015-03-01
影响因子：
10.6
通讯作者：
Potenza MN
中科院分区：
文献类型：
--
作者：
Balodis IM;Potenza MN
脑成像技术的进步使神经生物学研究能够暂时分析预期奖励的信号编码。在成瘾人群中，在预期普遍奖励时，涉及药物效应和奖励系统处理的大脑区域（如腹侧纹状体）的低反应和高反应都有报道。在这里，我们从一个广泛使用和验证的任务：货币激励延迟任务（MIDT）讨论成瘾障碍中奖励加工的知识现状。本文主要对MIDT在成瘾和高危成人中的应用研究进行综述，重点关注预期加工和任务执行过程中激活的纹状体区域，以及这些区域与个体差异（如冲动性）和治疗结果变量的关系。我们进一步回顾了药物在挑战研究中的影响，作为一种手段来检查对戒断、娱乐性使用和成瘾人群的奖励加工的急性影响。在这里，我们讨论了成瘾和高危人群的广义奖励处理通常以腹侧纹状体的发散预期信号为特征。虽然方法/任务的差异可能是一些差异发现的基础，但腹侧纹状体的预期信号也可能受到吸烟状况、药物代谢物和成瘾人群治疗状况的影响。在戒断、娱乐性使用和成瘾人群中得出的不同结果表明，解释这些发现很复杂。未来的研究将受益于集中描述冲动性和其他成瘾相关特征与预期纹状体信号的关系。此外，确定预期信号是如何在长期禁欲后恢复/调整的，这对于理解恢复过程非常重要。
Advances in brain imaging techniques have allowed neurobiological research to temporally analyze signals coding for the anticipation of rewards. In addicted populations, both hypo- and hyper-responsiveness of brain regions (e.g., ventral striatum) implicated in drug effects and reward system processing have been reported during anticipation of generalized reward. Here, we discuss the current state of knowledge of reward processing in addictive disorders from a widely used and validated task: the Monetary Incentive Delay Task (MIDT). The current paper constrains review to those studies applying the MIDT in addicted and at-risk adult populations, with a focus on anticipatory processing and striatal regions activated during task performance, as well as the relationship of these regions with individual difference (e.g., impulsivity) and treatment outcome variables. We further review drug influences in challenge studies as a means to examine acute influences on reward processing in abstinent, recreationally using and addicted populations. Here, we discuss that generalized reward processing in addicted and at-risk populations is often characterized by divergent anticipatory signaling in the ventral striatum. Although methodological/task variations may underlie some discrepant findings, anticipatory signaling in the ventral striatum may also be influenced by smoking status, drug metabolites and treatment status in addicted populations. Divergent results across abstinent, recreationally using and addicted populations demonstrate complexities in interpreting findings. Future studies will benefit from focusing on characterizing how impulsivity and other addiction-related features relate to anticipatory striatal signaling over time. Additionally, identifying how anticipatory signals recover/adjust following protracted abstinence will be important in understanding recovery processes.
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影响因子：
5.7
作者：
Abler, Birgit;Walter, Henrik;Spitzer, Manfred
通讯作者：
Spitzer, Manfred
DOI：
10.1111/j.1749-6632.2010.05898.x
发表时间：
2011-01-01
期刊：
ADDICTION REVIEWS
影响因子：
--
作者：
Hommer, Daniel W.;Bjork, James M.;Gilman, Jodi M.
通讯作者：
Gilman, Jodi M.
影响因子：
10.6
作者：
Jia, Zhiru;Worhunsky, Patrick D.;Carroll, Kathleen M.;Rounsaville, Bruce J.;Stevens, Michael C.;Pearlson, Godfrey D.;Potenza, Marc N.
通讯作者：
Potenza, Marc N.
影响因子：
4.8
作者：
Bjork, James M.;Smith, Ashley R.;Chen, Gang;Hommer, Daniel W.
通讯作者：
Hommer, Daniel W.
DOI：
10.1523/jneurosci.4515-08.2009
发表时间：
2009-04-08
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Croxson PL;Walton ME;O'Reilly JX;Behrens TE;Rushworth MF
通讯作者：
Rushworth MF