Pressure-induced constriction of the afferent arteriole of spontaneously hypertensive rats.
Pressure-induced constriction of the afferent arteriole of spontaneously hypertensive rats.
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压力引起的自发性高血压大鼠的传入小动脉收缩。
DOI：
10.1161/01.hyp.19.2_suppl.ii164
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Carretero,OA
中科院分区：
文献类型：
--
作者：
Ito,S;Juncos,LA;Carretero,OA
在无并发症的原发性高血压中，尽管肾灌注压升高，但肾血流量、肾小球滤过率和肾小球毛细血管压力均在正常范围内，表明肾小球前血管阻力异常高。在各种肾小球前血管段中，传入小动脉（Af-Art）被认为是产生最大阻力的部位。然而，人们对 Af-Art 的血管反应性或其对高血压的改变知之甚少。在这项研究中，我们测试了以下假设：自发性高血压大鼠 (SHR) 的 Af-Arts 中压力引起的收缩被夸大。从 SHR 和正常血压对照 Wistar-Kyoto (WKY) 大鼠的肾脏中显微解剖单个 Af-Arts，并在体外进行微灌注。当 Af-Art 中的压力从 20 毫米汞柱逐步增加到 80 毫米汞柱时，WKY 和 SHR Af-Arts 中的管腔直径类似地增加（分别从 10.0 +/- 0.8 到 18.6 +/- 1.3 微米和从 10.1 +/- 1.2 到 16.9 +/- 1.5 微米）。然而，当压力进一步增加到 140 mm Hg 时，WKY Af-Arts 的直径保持不变（19.2 +/- 1.9 微米），而 SHR 的直径则显着下降至 11.1 +/- 0.9 微米。我们的结论是，SHR Af-Arts 中压力引起的收缩被夸大，这可能有助于高血压的发生和维持。
In uncomplicated essential hypertension, renal blood flow, glomerular filtration rate, and glomerular capillary pressure are within the normal range despite elevated renal perfusion pressure, suggesting abnormally high resistance of the preglomerular vessels. Among various preglomerular vascular segments, the afferent arteriole (Af-Art) is thought to be the site responsible for most resistance. However, little is known about the vascular reactivity of the Af-Art or its alteration in hypertension. In this study, we tested the hypothesis that pressure-induced constriction is exaggerated in Af-Arts from spontaneously hypertensive rats (SHRs). Single Af-Arts were microdissected from kidneys of SHRs and normotensive control Wistar-Kyoto (WKY) rats and were microperfused in vitro. When pressure in the Af-Art was increased stepwise from 20 to 80 mm Hg, luminal diameter increased similarly in both WKY and SHR Af-Arts (from 10.0 +/- 0.8 to 18.6 +/- 1.3 microns and from 10.1 +/- 1.2 to 16.9 +/- 1.5 microns, respectively). However, when pressure was further increased to 140 mm Hg, the diameter remained unchanged in WKY Af-Arts (19.2 +/- 1.9 microns), whereas it decreased significantly to 11.1 +/- 0.9 microns in those from SHRs. We conclude that pressure-induced constriction is exaggerated in SHR Af-Arts, which may contribute to the development and maintenance of hypertension.
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通过去肾神经减弱 SHR 中增强的肾小管肾小球反馈活性。
DOI：
10.1152/ajprenal.1990.258.4.f980
发表时间：
1990
期刊：
The American journal of physiology
影响因子：
--
作者：
T. Takabatake;Y. Ushiogi;K. Ohta;N. Hattori
通讯作者：
N. Hattori
影响因子：
--
作者：
ARENDSHORST, WJ;BEIERWALTES, WH
通讯作者：
BEIERWALTES, WH
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DOI：
10.1152/ajprenal.1990.258.3.f741
发表时间：
1990
期刊：
The American journal of physiology
影响因子：
--
作者：
Yuan,BH;Robinette,JB;Conger,JD
通讯作者：
Conger,JD
研究致密斑介导的肾小球血流动力学的体外方法。
影响因子：
19.6
作者：
Ito,S;Carretero,OA
通讯作者：
Carretero,OA
影响因子：
--
作者：
AUKLAND, K;OIEN, AH
通讯作者：
OIEN, AH