Developmental changes in hippocampal shape among preadolescent children.
Developmental changes in hippocampal shape among preadolescent children.
复制标题
DOI：
10.1016/j.ijdevneu.2013.06.001
复制
发表时间：
2013-11
期刊：
影响因子：
--
通讯作者：
Su MY
中科院分区：
文献类型：
--
作者：
Lin M;Fwu PT;Buss C;Davis EP;Head K;Muftuler LT;Sandman CA;Su MY
众所周知，海马体最大的发育变化发生在产前期间和出生后的头两年。很少有研究已经进行，以解决正常的发展轨迹的海马在儿童时期。本研究应用形态分析方法对103名6 ~ 10岁发育正常的青春期前儿童海马进行了研究。将单个大脑标准化为模板，然后手动分割海马并进一步划分为头部，身体和尾部子区域。三种不同的方法应用于海马形状分析：径向距离映射，基于表面的模板注册使用鲁棒点匹配（RPM）算法，和基于体积的模板注册使用Demons算法。所有三种方法都表明，年龄较大的儿童与年龄较小的儿童相比，头段双侧扩大。基于到中心线的径向距离分析的结果与使用基于模板的配准方法分析的结果一致。在按性别分层的分析中，发现男孩和女孩的年龄相关解剖学变化相似，但女孩的年龄相关性最强。使用手动分割分析的总海马体积和子区域体积没有显示出显着的年龄相关性。我们的研究结果表明，形状分析是敏感的检测子区域的差异，没有透露在体积分析。本研究所提出的三种方法可应用于未来儿童海马正常发育轨迹的研究。它们可以进一步应用于检测幼儿正常发育轨迹的早期偏离，以评估涉及海马的精神病理学障碍的易感性。
It is known that the largest developmental changes in the hippocampus take place during the prenatal period and during the first two years of postnatal life. Few studies have been conducted to address the normal developmental trajectory of the hippocampus during childhood. In this study shape analysis was applied to study the normal developing hippocampus in a group of 103 typically-developing 6 to 10 year old preadolescent children. The individual brain was normalized to a template, and then the hippocampus was manually segmented and further divided into the head, body, and tail sub-regions. Three different methods were applied for hippocampal shape analysis: radial distance mapping, surface-based template registration using the robust point matching (RPM) algorithm, and volume-based template registration using the Demons algorithm. All three methods show that the older children have bilateral expanded head segments compared to the younger children. The results analyzed based on radial distance to the centerline were consistent with those analyzed using template-based registration methods. In analyses stratified by sex, it was found that the age-associated anatomical changes were similar in boys and girls, but the age-association was strongest in girls. Total hippocampal volume and sub-regional volumes analyzed using manual segmentation did not show a significant age-association. Our results suggest that shape analysis is sensitive to detect sub-regional differences that are not revealed in volumetric analysis. The three methods presented in this study may be applied in future studies to investigate the normal developmental trajectory of the hippocampus in children. They may be further applied to detect early deviations from the normal developmental trajectory in young children for evaluating susceptibility for psychopathological disorders involving hippocampus.
登录
查看更多内容
影响因子：
1.3
作者：
COLLINS, DL;NEELIN, P;EVANS, AC
通讯作者：
EVANS, AC
影响因子：
5.3
作者：
Ostby, Ylva;Tamnes, Christian K.;Walhovd, Kristine B.
通讯作者：
Walhovd, Kristine B.
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
影响因子：
3.7
作者：
Peper, Jiska S.;Brouwer, Rachel M.;Pol, Hilleke E. Hulshoff
通讯作者：
Pol, Hilleke E. Hulshoff
影响因子：
8.2
作者：
Andersen, SL
通讯作者：
Andersen, SL