Strategic vision for improving human health at The Forefront of Genomics.
Strategic vision for improving human health at The Forefront of Genomics.
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DOI：
10.1038/s41586-020-2817-4
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发表时间：
2020-10
期刊：
影响因子：
64.8
通讯作者：
Manolio TA
中科院分区：
文献类型：
--
作者：
Green ED;Gunter C;Biesecker LG;Di Francesco V;Easter CL;Feingold EA;Felsenfeld AL;Kaufman DJ;Ostrander EA;Pavan WJ;Phillippy AM;Wise AL;Dayal JG;Kish BJ;Mandich A;Wellington CR;Wetterstrand KA;Bates SA;Leja D;Vasquez S;Gahl WA;Graham BJ;Kastner DL;Liu P;Rodriguez LL;Solomon BD;Bonham VL;Brody LC;Hutter CM;Manolio TA
从三十年前人类基因组计划的启动开始，基因组学已经逐渐成为生物医学研究事业的基石。利用该项目于2003年成功完成的势头，基因组学现在经常在基础和转化研究中发挥核心和催化作用，研究越来越多地表明基因组信息在临床护理中可以发挥重要作用。展望未来，技术开发、生物学见解和临床应用（等）的预期进展将导致基因组学更广泛地整合到生物医学研究的几乎所有领域，基因组学被采用到主流医疗和公共卫生实践中，以及基因组学在日常生活中的相关性越来越大。国家人类基因组研究所代表研究界最近完成了一项多年战略参与进程，以收集关于人类基因组学未来研究优先事项和机会的投入，重点是健康应用。在这里，我们阐明了人类基因组学前沿的最高优先级元素，即在“基因组学的前沿”。
Starting with the launch of the Human Genome Project three decades ago, genomics has become progressively entrenched within the bedrock of the biomedical research enterprise. Capitalizing on the momentum of the project’s successful completion in 2003, genomics now regularly plays a central and catalytic role in basic and translational research, and studies increasingly demonstrate the vital role that genomic information can play in clinical care. Looking ahead, the anticipated advances in technology development, biological insights, and clinical applications (among others) will lead to more widespread integration of genomics into virtually all areas of biomedical research, the adoption of genomics into mainstream medical and public-health practices, and an increasing relevance of genomics in everyday life. On behalf of the research community, the National Human Genome Research Institute recently completed a multi-year process of strategic engagement to capture input about the future research priorities and opportunities in human genomics, with an emphasis on health applications. Here we articulate the highest-priority elements envisioned for the cutting-edge of human genomics going forward – that is, at “The Forefront of Genomics.”
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
DOI：
10.1056/nejmsr1809937
发表时间：
2019-08-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
All of Us Research Program Investigators;Denny JC;Rutter JL;Goldstein DB;Philippakis A;Smoller JW;Jenkins G;Dishman E
通讯作者：
Dishman E
影响因子：
16.6
作者：
Corbin LJ;Tan VY;Hughes DA;Wade KH;Paul DS;Tansey KE;Butcher F;Dudbridge F;Howson JM;Jallow MW;John C;Kingston N;Lindgren CM;O'Donavan M;O'Rahilly S;Owen MJ;Palmer CNA;Pearson ER;Scott RA;van Heel DA;Whittaker J;Frayling T;Tobin MD;Wain LV;Smith GD;Evans DM;Karpe F;McCarthy MI;Danesh J;Franks PW;Timpson NJ
通讯作者：
Timpson NJ
影响因子：
64.8
作者：
Collins, FS;Green, ED;Guyer, MS
通讯作者：
Guyer, MS
影响因子：
9.5
作者：
Attwood TK;Blackford S;Brazas MD;Davies A;Schneider MV
通讯作者：
Schneider MV