Dopamine modulates visual threat processing in the superior colliculus via D2 receptors.
Dopamine modulates visual threat processing in the superior colliculus via D2 receptors.
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DOI：
10.1016/j.isci.2022.104388
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发表时间：
2022-06-17
期刊：
影响因子：
5.8
通讯作者：
Wang, Liping
中科院分区：
文献类型：
--
作者：
Montardy, Quentin;Zhou, Zheng;Li, Lei;Yang, Qingning;Lei, Zhuogui;Feng, Xiaolong;Chen, Shanping;Shi, Qianqian;Zhang, Huiqi;Chen, Shuran;Zhang, Zhijian;Zhao, Binghao;Xu, Fuqiang;Lu, Zhonghua;Wang, Liping
Innate defensive responses, unlearned behaviors improving individuals’ chances of survival, have been found to involve the dopamine (DA) system. In the superior colliculus (SC), known for its role in defensive behaviors to visual threats, neurons expressing dopaminergic receptors of type 1 (Drd1+) and of type 2 (Drd2+) have been identified. We hypothesized that SC neurons expressing dopaminergic receptors may play a role in promoting innate defensive responses. Optogenetic activation of SC Drd2+ neurons, but not Drd1+ neurons, triggered defensive behaviors. Chemogenetic inhibition of SC Drd2+ neurons decreased looming-induced defensive behaviors, as well as pretreatment with the pharmacological Drd2+ agonist quinpirole, suggesting an essential role of Drd2 receptors in the regulation of innate defensive behavior. Input and output viral tracing revealed SC Drd2+ neurons mainly receive moderate inputs from the locus coeruleus (LC). Our results suggest a sophisticated regulatory role of DA and its receptor system in innate defensive behavior. Optogenetic activation of SC Drd2 + neurons, but not Drd1 + , induces defensive behaviors Repeated activation of SC Drd2 + provokes aversive memory and depression-like behavior Chemogenetic and pharmacological inhibition of SC Drd2 + impaired defensive behaviors Monosynaptic tracing revealed SC Drd2 + neurons mainly receive TH + projections from LC Biological sciences; Molecular neuroscience; Neuroscience
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影响因子：
3.5
作者：
Ito S;Feldheim DA
通讯作者：
Feldheim DA
神经元型特异性信号，用于腹侧对段区域的奖励和惩罚。
影响因子：
64.8
作者：
Cohen, Jeremiah Y.;Haesler, Sebastian;Vong, Linh;Lowell, Bradford B.;Uchida, Naoshige
通讯作者：
Uchida, Naoshige
DOI：
10.1126/science.1166112
发表时间：
2009-02-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hafed ZM;Goffart L;Krauzlis RJ
通讯作者：
Krauzlis RJ
影响因子：
4.7
作者：
Devoto, P;Flore, G;Gessa, GL
通讯作者：
Gessa, GL
影响因子：
3.4
作者：
Baldwin, Mary K. L.;Young, Nicole A.;Kaas, Jon H.
通讯作者：
Kaas, Jon H.