Influences of age and pubertal development on P300 amplitude trajectory across two years in female adolescents.
Influences of age and pubertal development on P300 amplitude trajectory across two years in female adolescents.
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DOI：
10.1016/j.dcn.2023.101212
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发表时间：
2023-04
影响因子：
4.7
通讯作者：
Hajcak, Greg
中科院分区：
文献类型：
--
作者：
Santopetro, Nicholas J.;Brush, C. J.;Mulligan, Elizabeth M.;Hajcak, Greg
P300事件相关电位（ERP）在人类一生中得到了广泛的研究。然而，许多研究检查年龄相关的影响是横截面，很少有人考虑到青春期发育可能对P300的发展轨迹的独特作用。目前的研究探讨了年龄，青春期成熟或其相互作用是否预测P300振幅在两年内的变化，在129名女性之间的8和15岁的基线。参与者完成侧翼任务，同时在基线和两年随访时记录EEG。基线年龄和青春期发育的增加与随访时较小的P300振幅相关。然而，年龄的影响是合格的年龄和青春期成熟之间的相互作用：在年轻的女孩，增加青春期发育预测P300的下降，而减少青春期发育预测P300的增加。这些数据表明，青春期的时间影响P300振幅的神经发育变化-例如，8至10岁女孩的青春期发育高与低预测神经活动的差异轨迹。鉴于P300降低与抑郁症等心理健康障碍之间的联系，未来的研究可能会研究受早发性青春期发育影响的神经发育变化是否可以解释这些心理健康问题的增加。过去的研究表明，随着儿童的发育，视觉P300振幅会降低。这些研究大多数是横断面的，很少有研究探讨年龄和青春期之间的P300的动态。最初，年龄，而不是青春期的发展，唯一预测P300振幅随时间的变化。然而，年龄和青春期发育显着相互作用，预测P300振幅的变化超过两年。这一发现暗示了青春期早期对儿童和青春期神经发育的作用。
The P300 event-related potential (ERP) has been extensively studied across the human lifespan. However, many studies examining age-related effects are cross-sectional, and few have considered the unique role that pubertal development may have on P300 developmental trajectories. The current study examined whether age, pubertal maturation or their interaction predicted changes in P300 amplitude over two years among 129 females between the ages of 8 and 15 years at baseline. Participants completed a flanker task while EEG was recorded at a baseline and two-year follow-up visit. Both baseline age and increased pubertal development were associated with smaller P300 amplitude at follow-up. However, the influence of age was qualified by an interaction between age and pubertal maturation: among younger girls only, increased pubertal development predicted decreases in P300, whereas decreased pubertal development predicted increases in P300. These data indicate that pubertal timing impacts neurodevelopmental changes in P300 amplitude – such that high versus low pubertal development among 8- to 10-year-old girls predicted differential trajectories of neural activity. In light of links between reduced P300 and mental health disorders, such as depression, future studies might examine whether neurodevelopmental changes influenced by early-onset pubertal development could account for increases in these mental health problems. Past work has shown reduced visual P300 amplitude as children develop. Majority of these studies are cross-sectional and few studies have examined the dynamics between age and puberty on P300. Initially, age, but not pubertal development, uniquely predicted change in P300 amplitude over time. However, age and pubertal development significantly interacted to predict changes in P300 amplitude over two years. This finding implicates the role of early pubertal timing on neurodevelopment during childhood and adolescence.
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