Molecular constitution of breast but not other reproductive tissues is rich in growth promoting molecules: a possible link to highest incidence of tumor growths.
Molecular constitution of breast but not other reproductive tissues is rich in growth promoting molecules: a possible link to highest incidence of tumor growths.
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DOI：
10.1016/j.febslet.2009.08.021
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发表时间：
2009-09-17
期刊：
影响因子：
3.5
通讯作者：
Bonney, George
中科院分区：
文献类型：
--
作者：
Poola, Indira;Abraham, Jessy;Marshalleck, Josephine J.;Yue, Qingqi;Fu, Sidney W.;Viswanath, Lokesh;Sharma, Nikhil;Hill, Russel;DeWitty, Robert L.;Bonney, George
在目前的研究中，我们测试了乳腺组织中良性和癌症生长的最高发生率是否是由于该组织的组成性分子组成。为了描述分子基础，我们比较了9个功能基因模块（共578个基因）的表达，这些基因模块调节正常乳腺与其他两个生殖组织（卵巢和子宫）中主要的正向生长和负向抑制信号。我们目前的数据表明，乳腺组织组成有非常高的几种生长促进分子和抑制分子的水平降低，这可能是部分，有助于肿瘤生长在该组织中的最高发病率。
In the current study we tested if highest incidence of benign as well as cancer growths in breast tissue is due to constitutive molecular composition of this tissue. To delineate the molecular basis, we compared the expression of nine functional gene modules (total 578 genes) that regulate major positive growth and negative inhibitory signals in normal breast with two other reproductive tissues, ovary and uterus. We present data to demonstrate that breast tissues constitutively have very highly elevated levels of several growth promoting molecules and diminished levels of inhibitory molecules which may, in part, contribute for highest incidence of tumor growths in this tissue.
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