Coronary Blood Flow Is Increased in RV Hypertrophy, but the Shape of Normalized Waves Is Preserved Throughout the Arterial Tree.
Coronary Blood Flow Is Increased in RV Hypertrophy, but the Shape of Normalized Waves Is Preserved Throughout the Arterial Tree.
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右心室肥厚时冠状动脉血流量增加，但整个动脉树保持正常波的形状
DOI：
10.3389/fphys.2018.00675
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发表时间：
2018
影响因子：
4
通讯作者：
Kassab GS
中科院分区：
文献类型：
--
作者：
Huo Y;Kassab GS
在对照和RV肥大（RVH）心脏的右冠状动脉（RCA）树中进行脉动血流动力学分析。假设血流和壁面剪切应力（WSS）波的形状在RVH中的整个RCA树中保持不变（即，不同尺寸血管中的标准化血流和WSS波的相似模式）。因此，我们根据测量的形态学数据重建了整个RCA树，直至对照组和RVH心脏的第一个毛细血管分叉。Womersley型模型用于计算树中的流动和WSS波。从实验测量获得的血流动力学参数被纳入到数值模型。在小动脉数目增加的情况下，RVH组RCA树入口处的平均血流波和振幅比对照组大2倍，但毛细血管前小动脉的血流波无显著性差异（p > 0.05）。RVH的RCA刚度增加保持了标准化血流和WSS波的形状，但增加了冠状动脉的PWV，并减少了最近端RCA和最远端毛细血管前小动脉之间的波的相位角差。该研究对了解心室肥厚时的搏动性冠状动脉血流具有重要意义。
A pulsatile hemodynamic analysis was carried out in the right coronary arterial (RCA) tree of control and RV hypertrophy (RVH) hearts. The shape of flow and wall shear stress (WSS) waves was hypothesized to be maintained throughout the RCA tree in RVH (i.e., similar patterns of normalized flow and WSS waves in vessels of various sizes). Consequently, we reconstructed the entire RCA tree down to the first capillary bifurcation of control and RVH hearts based on measured morphometric data. A Womersley-type model was used to compute the flow and WSS waves in the tree. The hemodynamic parameters obtained from experimental measurements were incorporated into the numerical model. Given an increased number of arterioles, the mean and amplitude of flow waves at the inlet of RCA tree in RVH was found to be two times larger than that in control, but no significant differences (p > 0.05) were found in precapillary arterioles. The increase of stiffness in RCA of RVH preserved the shape of normalized flow and WSS waves, but increased the PWV in coronary arteries and reduced the phase angle difference for the waves between the most proximal RCA and the most distal precapillary arteriole. The study is important for understanding pulsatile coronary blood flow in ventricular hypertrophy.
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种内标度法则在心室肥厚中保留，但在心力衰竭中不保留。
DOI：
10.1152/ajpheart.00084.2016
发表时间：
2016-11-01
影响因子：
4.8
作者：
Gong, Yanjun;Feng, Yundi;Kassab, Ghassan S.
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影响因子：
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通讯作者：
Kassab, Ghassan S.
影响因子：
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作者：
Chiu JJ;Chien S
通讯作者：
Chien S
影响因子：
3.8
作者：
Mittal, N;Zhou, Y;Kassab, GS
通讯作者：
Kassab, GS