Genetic epidemiology of attention deficit hyperactivity disorder (ADHD index) in adults.
Genetic epidemiology of attention deficit hyperactivity disorder (ADHD index) in adults.
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DOI：
10.1371/journal.pone.0010621
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发表时间：
2010-05-12
期刊：
影响因子：
3.7
通讯作者：
Willemsen G
中科院分区：
文献类型：
--
作者：
Boomsma DI;Saviouk V;Hottenga JJ;Distel MA;de Moor MH;Vink JM;Geels LM;van Beek JH;Bartels M;de Geus EJ;Willemsen G
与大量的儿童研究相反，关于遗传因素对成人注意缺陷多动障碍（ADHD）的影响的信息很少。通过CAARS（Conners' Adult ADHD Rating Scales）中的ADHD指数评估成人ADHD的遗传度。使用遗传结构方程模型分析了在荷兰双胞胎登记处登记的12，000多名成年人（双胞胎，兄弟姐妹和父母）的表型数据。ADHD的遗传力估计来自双胞胎家庭研究。成人ADHD的遗传率估计在男性和女性中约为30%。有一些证据表明，有选择性交配。所有的家庭传播都是通过遗传来解释的，没有证据支持从父母到后代的文化传播是重要的这一假设。成人ADHD特征的遗传率是存在的，但远低于儿童。
In contrast to the large number of studies in children, there is little information on the contribution of genetic factors to Attention Deficit Hyperactivity Disorder (ADHD) in adults. To estimate the heritability of ADHD in adults as assessed by the ADHD index scored from the CAARS (Conners' Adult ADHD Rating Scales). Phenotype data from over 12,000 adults (twins, siblings and parents) registered with the Netherlands Twin Register were analyzed using genetic structural equation modeling. Heritability estimates for ADHD from the twin-family study. Heritability of ADHD in adults is estimated around 30% in men and women. There is some evidence for assortative mating. All familial transmission is explained by genetic inheritance, there is no support for the hypothesis that cultural transmission from parents to offspring is important. Heritability for ADHD features in adults is present, but is substantially lower than it is in children.
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影响因子：
6.4
作者：
Banaschewski, Tobias;Becker, Katja;Scherag, Susann;Franke, Barbara;Coghill, David
通讯作者：
Coghill, David
影响因子：
5.3
作者：
Franke B;Neale BM;Faraone SV
通讯作者：
Faraone SV
影响因子：
11
作者：
Asherson, P.;Zhou, K.;Faraone, S. V.
通讯作者：
Faraone, S. V.
影响因子：
5.1
作者：
Kahn, RS;Khoury, J;Lanphear, BP
通讯作者：
Lanphear, BP
影响因子：
3
作者：
Faraone, Stephen V;Biederman, Joseph
通讯作者：
Biederman, Joseph