Pedunculopontine tegmental nucleus neurons provide reward, sensorimotor, and alerting signals to midbrain dopamine neurons.
Pedunculopontine tegmental nucleus neurons provide reward, sensorimotor, and alerting signals to midbrain dopamine neurons.
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DOI：
10.1016/j.neuroscience.2014.07.002
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发表时间：
2014-12-12
期刊：
影响因子：
3.3
通讯作者：
Hikosaka, O.
中科院分区：
文献类型：
--
作者：
Hong, S.;Hikosaka, O.
中脑中的多巴胺（DA）神经元对于行为的动机控制至关重要。然而，最近的研究表明，DA神经元传递的信号是异质的。这可能反映了DA神经元的广泛输入，但哪些信号由哪些大脑区域提供仍然不清楚。在这里，我们专注于脚桥被盖核（PPTg）在猕猴和特点的输入DA神经元。由于PPTg投射到许多大脑区域，因此识别投射到DA神经元区域的PPTg神经元至关重要。为此，我们使用逆向激活技术，通过电刺激三个位置（内侧，中央，外侧）在黑质pars延髓（SNc）。我们发现SNc投射神经元主要位于PPTg，也有部分位于楔状核（CuN）。电刺激SNc投射的PPTg区域在假定的DA神经元中诱导尖峰脉冲的爆发，表明PPTg-DA（SNc）连接是兴奋性的。行为任务和临床试验表明，SNc投射PPTg神经元编码奖励，感觉运动和唤醒/报警信号。重要的是，奖励相关的PPTg神经元倾向于投射到内侧和中央SNc，而感觉运动/唤醒/警觉相关的PPTg神经元倾向于投射到外侧SNc。大多数奖励相关的信号是积极的偏见：兴奋和抑制时，更好和更坏的奖励预期，分别。这些PPTg神经元倾向于保留奖励值信号，直到奖励结果之后，代表“价值状态”;这与DA神经元不同，DA神经元显示代表“价值变化”的相位信号。我们的数据，加上以前的研究，表明，PPTg神经元发送积极的奖励相关的信号，主要是到内侧中央SNc的DA神经元编码的动机值和感觉/唤醒信号的侧SNc的DA神经元编码的动机显着性。
Dopamine (DA) neurons in the midbrain are crucial for motivational control of behavior. However, recent studies suggest that signals transmitted by DA neurons are heterogeneous. This may reflect a wide range of inputs to DA neurons, but which signals are provided by which brain areas is still unclear. Here we focused on the pedunculopontine tegmental nucleus (PPTg) in macaque monkeys and characterized its inputs to DA neurons. Since the PPTg projects to many brain areas, it is crucial to identify PPTg neurons that project to DA neuron areas. For this purpose we used antidromic activation technique by electrically stimulating three locations (medial, central, lateral) in the substantia nigra pars compacta (SNc). We found SNc-projecting neurons mainly in the PPTg, and some in the cuneiform nucleus (CuN). Electrical stimulation in the SNc-projecting PPTg regions induced a burst of spikes in presumed DA neurons, suggesting that the PPTg-DA(SNc) connection is excitatory. Behavioral tasks and clinical tests showed that the SNc-projecting PPTg neurons encoded reward, sensorimotor and arousal/alerting signals. Importantly, reward-related PPTg neurons tended to project to the medial and central SNc, whereas sensorimotor/arousal/alerting-related PPTg neurons tended to project to the lateral SNc. Most reward-related signals were positively biased: excitation and inhibition when a better and worse reward was expected, respectively. These PPTg neurons tended to retain the reward value signal until after a reward outcome, representing ‘value state’; this was different from DA neurons which show phasic signals representing ‘value change’. Our data, together with previous studies, suggest that PPTg neurons send positive reward-related signals mainly to the medial-central SNc where DA neurons encode motivational values and sensorimotor/arousal signals to the lateral SNc where DA neurons encode motivational salience.
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影响因子：
2.5
作者：
Balcita-Pedicino, Judith Joyce;Omelchenko, Natalia;Bell, Roland;Sesack, Susan R.
通讯作者：
Sesack, Susan R.
影响因子：
3.3
作者：
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通讯作者：
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影响因子：
2.5
作者：
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影响因子：
16.2
作者：
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通讯作者：
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影响因子：
2.9
作者：
FUTAMI, T;TAKAKUSAKI, K;KITAI, ST
通讯作者：
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