Estimates of seasonal influenza-associated mortality in Bangladesh, 2010-2012.
Estimates of seasonal influenza-associated mortality in Bangladesh, 2010-2012.
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DOI：
10.1111/irv.12490
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发表时间：
2018-01
影响因子：
4.4
通讯作者：
Danielle Iuliano A
中科院分区：
文献类型：
--
作者：
Ahmed M;Aleem MA;Roguski K;Abedin J;Islam A;Alam KF;Gurley ES;Rahman M;Azziz-Baumgartner E;Homaira N;Sturm-Ramirez K;Danielle Iuliano A
季节性流感相关死亡率估计有助于确定疾病负担和评估公共卫生干预措施的价值，例如每年接种流感疫苗。孟加拉国的生命登记有限，因此很难估计季节性流感死亡率。我们的研究旨在估计孟加拉国2010-2012年季节性流感相关死亡率。我们在孟加拉国的11个地点对5岁以下的严重急性呼吸道疾病(≥)患者和5岁以下儿童的严重肺炎住院患者进行了监测。我们确定了这些地点的集水区，并在集水区内随机选择的22个工会(行政单位)进行了社区调查，以确定呼吸道死亡的情况。我们将监测点流感阳性患者的比例乘以确定的特定年龄段的呼吸道死亡人数，以估计季节性流感相关死亡人数。在4221例监测病例中，553例(13%)流感病毒阳性。与此同时，我们确认了在监测医院的集水区内发生急性呼吸道疾病后两周内死亡的1191人。2010-2011年，儿童及5岁儿童流感相关死亡率估计为6/10万(95%可信区间4-9)，60岁儿童死亡率为41/10万(95%可信区间35-47)。2011-2012年间，流感相关死亡率在5岁以下儿童中为13/10万(95%可信区间10-16)，在60岁以上人群中为88/10万(95%可信区间79-98)。我们确定了孟加拉国流感相关死亡的巨大负担，这表明当地公共卫生决策者应考虑采取预防和控制措施，包括季节性接种疫苗。
Seasonal influenza‐associated mortality estimates help identify the burden of disease and assess the value of public health interventions such as annual influenza immunization. Vital registration is limited in Bangladesh making it difficult to estimate seasonal influenza mortality. Our study aimed to estimate seasonal influenza‐associated mortality rates for 2010‐2012 in Bangladesh. We conducted surveillance among hospitalized patients with severe acute respiratory illness (SARI) for persons aged ≥5 years and severe pneumonia for children <5 years in 11 sites across Bangladesh. We defined the catchment areas of these sites and conducted a community survey in 22 randomly selected unions (administrative units) within the catchment areas to identify respiratory deaths. We multiplied the proportion of influenza‐positive patients at our surveillance sites by the age‐specific number of respiratory deaths identified to estimate seasonal influenza‐associated mortality. Among 4221 surveillance case‐patients, 553 (13%) were positive for influenza viruses. Concurrently, we identified 1191 persons who died within 2 weeks of developing an acute respiratory illness within the catchment areas of the surveillance hospitals. In 2010‐2011, the estimated influenza‐associated mortality rate was 6 (95% CI 4‐9) per 100 000 for children <5 years and 41 (95% CI 35‐47) per 100 000 for persons >60 years. During 2011‐2012, the estimated influenza‐associated mortality rate was 13 (95% CI 10‐16) per 100 000 among children <5 years and 88 (95% CI 79‐98) per 100 000 among persons aged >60 years. We identified a substantial burden of influenza‐associated deaths in Bangladesh suggesting that the introduction of prevention and control measures including seasonal vaccination should be considered by local public health decision‐makers.
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影响因子：
5.1
作者：
Godoy P;Castilla J;Delgado-Rodríguez M;Martín V;Soldevila N;Alonso J;Astray J;Baricot M;Cantón R;Castro A;González-Candelas F;Mayoral JM;Quintana JM;Pumarola T;Tamames S;Domínguez A;CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain
通讯作者：
CIBERESP Cases and Controls in Pandemic Influenza Working Group, Spain
影响因子：
5.2
作者：
Florescu DF;Kalil AC
通讯作者：
Kalil AC
DOI：
10.4269/ajtmh.2011.10-0706
发表时间：
2011-08-01
影响因子：
3.3
作者：
Paul, Repon C.;Rahman, Mahmudur;Luby, Stephen P.
通讯作者：
Luby, Stephen P.
影响因子：
39.2
作者：
Cowling, Benjamin J.;Chan, Kwok-Hung;Leung, Gabriel M.
通讯作者：
Leung, Gabriel M.
影响因子：
4.4
作者：
Cheng, Po-Yung;Palekar, Rakhee;Widdowson, Marc-Alain
通讯作者：
Widdowson, Marc-Alain