Natural selection mediated association of the Duffy (FY) gene polymorphisms with Plasmodium vivax malaria in India.
Natural selection mediated association of the Duffy (FY) gene polymorphisms with Plasmodium vivax malaria in India.
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DOI：
10.1371/journal.pone.0045219
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Das A
中科院分区：
文献类型：
--
作者：
Chittoria A;Mohanty S;Jaiswal YK;Das A
达菲 (Fy) 抗原充当趋化因子以及间日疟原虫侵入人类红细胞的受体。最近的一项研究将 Duffy 基因 FY*A 等位基因的出现与间日疟疾易感性降低相关，但迄今为止尚未确定 FY*A 等位基因的分布与间日疟疾发病率之间的流行病学相关性。此外，如果存在这种相关性，自然选择是否介导了这种关联，是一个重要的问题。由于印度是间日疟疾的高流行地区，不同地区的生态气候和间日疟流行病学也不同，因此印度人很可能回答这个问题。为此，我们对覆盖整个印度的 6 个不同地区和 1 个部落人口的 250 名印度人的第 -33 和 125 个核苷酸位置处的 FY 基因进行了基因分型，并研究了与生态气候和间日疟疾发病率的可能相关性。没有发现FY * O等位基因，但形成FY * A / FY * A，FY * A / FY * B和FY * B / FY * B基因型的FY * A和FY * B等位基因在印度人中广泛分布。七个群体样本中有五个显着偏离 Hardy-Weinberg 平衡预期，并且两个等位基因（FY*A 和 FY*B）和纯合子基因型 FY*B/FY*B 临床分布在群体坐标上。此外，过去五年间日疟疾发病率分别与 FY*A 和 FY*B 等位基因的频率显着负相关和正相关。正如重建的邻接系统发育树所证明的那样，北印第安人在 FY 基因上与其他区域种群样本存在高度差异。结果明确了自然选择在印度 FY 基因多态性分布中的作用。此外，FY*A 等位基因对间日疟具有保护作用的假设可以在印度等间日疟流行病学环境中进行群体遗传学研究后得到验证。
The Duffy (Fy) antigens act as receptors for chemokines as well as for Plasmodium vivax to invade human RBCs. A recent study has correlated the occurrence of the FY*A allele of Duffy gene with decreased susceptibility to vivax malaria, but no epidemiological correlation between the distribution of FY*A allele and incidences of vivax malaria has been established so far. Furthermore, if such correlations exist, whether natural selection has mediated the association, is an important question. Since India is highly endemic to P. vivax malaria with variable eco-climatic and varying vivax malaria epidemiology across different regions, such a question could well be answered in Indians. For this, we have genotyped the FY gene at the −33rd and the 125th nucleotide positions in 250 Indians sampled from six different zonal plus one tribal population covering the whole of India and studied possible correlations with eco-climatic and vivax malaria incidences. No FY*O allele was found, however, both the FY*A and FY*B alleles forming FY*A/FY*A, FY*A/FY*B and FY*B/FY*B genotypes were widely distributed among Indians. Five out of seven population samples significantly deviated from the Hardy-Weinberg equilibrium expectation, and two alleles (FY*A and FY*B) and the homozygote genotype, FY*B/FY*B were clinally distributed over the population coordinates. Furthermore, vivax malaria incidences over the past five years were significantly negatively and positively associated with the frequencies of the FY*A and FY*B alleles, respectively. The Northern Indians were highly differentiated from the other zonal population samples at the FY gene, as evidenced from the reconstructed Neighbor-Joining phylogenetic tree. The results specify the role of natural selection in the distribution of FY gene polymorphism in India. Furthermore, the hypotheses on the part of the FY*A allele in conferring protection to vivax malaria could be validated following population genetic studies in a vivax malaria epidemiological setting, such as India.
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影响因子：
2.7
作者：
Das, Aparup;Anvikar, Anupkumar R.;Valecha, Neena
通讯作者：
Valecha, Neena
影响因子：
1.8
作者：
KAR, S;SETH, S;SETH, PK
通讯作者：
SETH, PK
影响因子：
158.5
作者：
MILLER, LH;MASON, SJ;MCGINNISS, MH
通讯作者：
MCGINNISS, MH
DOI：
10.1098/rspb.1955.0047
发表时间：
1955-01-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
PENROSE, LS
通讯作者：
PENROSE, LS
影响因子：
16.6
作者：
Howes, Rosalind E.;Patil, Anand P.;Piel, Frederic B.;Nyangiri, Oscar A.;Kabaria, Caroline W.;Gething, Peter W.;Zimmerman, Peter A.;Barnadas, Celine;Beall, Cynthia M.;Gebremedhin, Amha;Menard, Didier;Williams, Thomas N.;Weatherall, David J.;Hay, Simon I.
通讯作者：
Hay, Simon I.