Stiffness versus prestress relationship at subcellular length scale.

Stiffness versus prestress relationship at subcellular length scale.
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DOI:
10.1016/j.jbiomech.2014.08.004
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发表时间:
2014-09-22
影响因子:
2.4
通讯作者:
Stamenovic, Dimitrije
Stamenovic, Dimitrije
中科院分区:
工程技术3区
文献类型:
--
作者:
Canovic, Elizabeth P.;Seidl, D. Thomas;Barbone, Paul E.;Smith, Michael L.;Stamenovic, Dimitrije

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细胞机械性能的局部细胞内变化,这是至关重要的细胞功能,还没有得到很好的表征和了解甚少。在这里,我们使用我们以前的生物力学成像研究的结果,以获得细胞内剪切模量和预应力之间的关系。我们发现,亚细胞剪切模量与预应力的关系表现出正的线性相关性,与以前观察到的行为在整个细胞和组织水平。这反过来又表明,预应力可能是一个统一的因素,决定在不同的长度尺度的活物质的材料特性。
Local intracellular variations of cell mechanical properties, which are essential for vital cellular functions, have not been well characterized and are poorly understood. Here, we used results from our previous biomechanical imaging study to obtain relationships between intracellular shear modulus and prestress. We found that the subcellular shear modulus vs. prestress relationships exhibited positive linear correlations, consistent with previously observed behaviors at the whole cell and tissue levels. This, in turn, suggests that the prestress may be a unifying factor that determines material properties of living matter at different length scales.
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