Ca(2+) signaling, genes and the cell cycle.
Ca(2+) signaling, genes and the cell cycle.
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DOI：
10.1016/j.ceca.2010.10.003
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发表时间：
2010-11
期刊：
影响因子：
4
通讯作者：
Machaca K
中科院分区：
文献类型：
--
作者：
Machaca K
细胞质中Ca2+离子浓度和空间分布的变化构成了细胞生理学中普遍存在的胞内信号传导模块。随着Ca2+染料的出现，允许直接可视化Ca2+瞬态，结合强大的实验工具，如电生理记录，细胞内Ca2+瞬态几乎涉及细胞生理学的各个方面，包括细胞增殖。Ca2+信号与细胞周期的不同阶段有关，干扰Ca2+信号或下游途径通常会破坏细胞周期的进展。尽管Ca2+信号与细胞周期之间存在依赖关系，但所涉及的机制尚未很好地定义，并且考虑到Ca2+和其他信号模块之间的串扰，很难评估Ca2+信号在细胞周期进程中的确切作用。然而，有两个例外，包括受精和t细胞活化，其中Ca2+信号在细胞周期的特定阶段介导进展的明确作用已经明确确立。在t细胞活化的情况下，Ca2+通过诱导基因转录调节进入细胞周期。
Changes in the concentration and spatial distribution of Ca2+ ions in the cytoplasm constitute a ubiquitous intracellular signaling module in cellular physiology. With the advent of Ca2+ dyes that allow direct visualization of Ca2+ transients, combined with powerful experimental tools such as electrophysiological recordings, intracellular Ca2+ transients have been implicated in practically every aspect of cellular physiology, including cellular proliferation. Ca2+ signals are associated with different phases of the cell cycle and interfering with Ca2+ signaling or downstream pathways often disrupts progression of the cell cycle. Although there exists a dependence between Ca2+ signals and the cell cycle the mechanisms involved are not well defined and given the cross-talk between Ca2+ and other signaling modules, it is difficult to assess the exact role of Ca2+ signals in cell cycle progression. Two exceptions however, include fertilization and T-cell activation, where well-defined roles for Ca2+ signals in mediating progression through specific stages of the cell cycle have been clearly established. In the case of T-cell activation Ca2+ regulates entry into the cell cycle through the induction of gene transcription.
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影响因子：
3.7
作者：
CLOTHIER, G;TIMOURIAN, H
通讯作者：
TIMOURIAN, H
影响因子：
2.7
作者：
CORK, RJ;CICIRELLI, MF;ROBINSON, KR
通讯作者：
ROBINSON, KR
DOI：
10.1083/jcb.111.5.1763
发表时间：
1990-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Baitinger C;Alderton J;Poenie M;Schulman H;Steinhardt RA
通讯作者：
Steinhardt RA
由三磷酸肌醇水平周期性变化驱动的细胞周期钙离子瞬变
影响因子：
64.8
作者：
CIAPA, B;PESANDO, D;WHITAKER, M
通讯作者：
WHITAKER, M
影响因子：
2.7
作者：
El-Jouni, W;Jang, B;Machaca, K
通讯作者：
Machaca, K