Morphological alterations of the corpus callosum in antipsychotic-naive first-episode schizophrenia before and 1-year after treatment
Morphological alterations of the corpus callosum in antipsychotic-naive first-episode schizophrenia before and 1-year after treatment
复制标题
未接受抗精神病药物治疗的首发精神分裂症患者治疗前和治疗后一年胼胝体的形态学变化
DOI：
10.1016/j.schres.2021.03.015
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Lui S
中科院分区：
文献类型：
--
作者：
Tao B;Xiao Y;Yang B;Zeng J;Zhang W;Hu N;Yang C;Lencer R;Gong Q;Sweeney JA;Lui S
目的已知精神分裂症患者的胼胝体(CC)会发生改变。然而，在初治的首发精神分裂症患者中，其形态特征以及抗精神病药物治疗对这一结构的影响研究较少。方法对160例初治的首发精神分裂症患者(AN-FES)和155名健康对照(HCS)在治疗开始前进行T-1加权MRI扫描。在这些患者中，44人在抗精神病药物治疗一年后可用于随访研究，并根据阳性和阴性症状量表(PANSS)总分是否较基线下降50%分为结果良好(n=31)和结果差(n=13)亚组。应用计算机算法自动识别中矢状面(MSP)，获得CC的形态测量参数。结果与HCS相比，AN-FES患者CC中段后段厚度明显减少。这一缺陷与阴性症状的严重程度相关。经抗精神病药物治疗1年后，精神分裂症患者CC形态测量值无明显变化，预后良好亚组与预后不良亚组的CC形态测量值在基线及1年随访时均无显著差异。结论精神分裂症患者治疗前早期CC后部中段厚度减少。这种改变不受抗精神病药物治疗的影响，与1年后的治疗结果无关。
ObjectiveThe corpus callosum (CC) is known to be altered in patients with schizophrenia. However, its morphologic characteristics are less well studied in treatment-naive first-episode schizophrenia patients, as is the effect of antipsychotic treatment on this structure.MethodsT-1 weighted MRI scans were obtained from 160 antipsychotic-naïve first-episode schizophrenia patients (AN-FES) and 155 healthy controls (HCs) before treatment initiation. Among the patients, forty-four were available for follow-up studies after one year of antipsychotic treatment, and were divided into good-outcome (n= 31) and poor-outcome subgroups (n= 13) based on whether there was a 50% reduction in Positive and Negative Symptom Scale (PANSS) total scores from baseline. A computer algorithm was applied to automatically identify the mid-sagittal plane (MSP) and obtain morphological measurement parameters of the CC.ResultsCompared with HCs, AN-FES patients showed a significant reduction of thickness in the posterior midbody of the CC. This deficit was correlated with severity of negative symptoms. After one year of antipsychotic treatment, there was no significant change in CC morphological measurements in schizophrenia patients, nor was there a significant difference of CC morphological measurements between good-outcome and poor-outcome subgroups at baseline or at 1-year follow-up.ConclusionThickness of the posterior midbody of the CC is reduced in the early course of schizophrenia before treatment. This alteration was not affected by antipsychotic treatment and was unrelated to treatment outcome at 1-year.
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