Oxytocin action in the ventral tegmental area affects sucrose intake.
Oxytocin action in the ventral tegmental area affects sucrose intake.
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DOI：
10.1016/j.brainres.2013.03.026
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发表时间：
2013-06-04
期刊：
影响因子：
2.9
通讯作者：
Williams DL
中科院分区：
文献类型：
--
作者：
Mullis K;Kay K;Williams DL
众所周知，大脑催产素在控制食物摄入方面发挥着作用，最近的研究表明，刺激中枢催产素受体可以选择性地抑制碳水化合物的摄入。参与这种反应的特定催产素投射位点和受体群尚未确定。我们假设腹侧被盖区 (VTA) 中的催产素受体可能在限制蔗糖摄入量方面发挥作用，因为已知 VTA 会影响可口的食物摄入量。我们首先进行了剂量反应研究，其中我们观察到，在 30 分钟的测试过程中，VTA 内注射催产素显着抑制了 10% 蔗糖溶液的摄入量，相对于载体治疗而言，抑制量为 13.35% - 20.5%。抑制蔗糖摄入的 VTA 内催产素剂量对水摄入量没有影响。接下来我们检查了两种催产素受体拮抗剂 (d(CH2)51,Tyr(Me)2,Orn8)-催产素 (OVT) 和 L-368,899 的作用。当直接递送至VTA时，这些拮抗剂中的每一种均显着增加10%蔗糖摄入量17% - 20.5%，如果注射至脑室，其剂量低于阈值。最后，我们观察到，L-368,899 预处理显着减弱了 VTA 内催产素抑制 10% 蔗糖摄入的作用，这支持了 VTA 催产素治疗通过作用于催产素受体来抑制摄入的建议。这些发现支持 VTA 内的内源性催产素作用抑制蔗糖摄入的观点。我们得出结论，VTA 中的催产素受体在控制蔗糖摄入中发挥生理作用。
Brain oxytocin is known to play a role in the control of food intake, and recent studies suggest that stimulation of central oxytocin receptors selectively suppresses carbohydrate intake. The specific oxytocin projection sites and receptor populations involved in this response are as yet unidentified. We hypothesized that oxytocin receptors in the ventral tegmental area (VTA) may play a role in limiting sucrose intake, because the VTA is known to influence palatable food intake. We first performed a dose response study in which we observed that intra-VTA oxytocin injection significantly suppressed intake of a 10% sucrose solution during a 30-min test session by 13.35% - 20.5% relative to vehicle treatment. Doses of intra-VTA oxytocin that suppressed sucrose intake had no effect on water intake. Next we examined the effects of two oxytocin receptor antagonists, (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin (OVT) and L-368,899. Each of these antagonists significantly increased 10% sucrose intake by 17% - 20.5% relative to vehicle when delivered directly into the VTA, at doses subthreshold for effect if injected into the cerebral ventricles. Finally, we observed that the effect of intra-VTA oxytocin to suppress 10% sucrose intake was significantly attenuated by pretreatment with L-368,899, supporting the suggestion that the VTA oxytocin treatment suppresses intake through action at oxytocin receptors. These findings support the suggestion that endogenous oxytocin action within the VTA suppresses sucrose intake. We conclude that oxytocin receptors in the VTA play a physiologic role in the control of sucrose ingestion.
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