Neonatal and infantile immune responses to encapsulated bacteria and conjugate vaccines.
Neonatal and infantile immune responses to encapsulated bacteria and conjugate vaccines.
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DOI：
10.1155/2008/628963
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发表时间：
2008
影响因子：
--
通讯作者：
Bont L
中科院分区：
文献类型：
--
作者：
Klein Klouwenberg P;Bont L
被包裹的细菌是造成新生儿和婴儿死亡的主要原因。这些细菌表面的主要成分是多糖，多糖是重要的毒力因子。对这些成分的免疫可以预防疾病。然而，大多数多糖是胸腺非依赖性(TI)-2抗原，在新生儿和婴儿中诱导不充分的免疫反应。该机制被认为在这个年龄组对TI-2刺激无反应中起作用，我们将讨论。免疫反应的缺乏可以通过将多糖偶联到载体蛋白上来克服。这将细菌多糖从TI-2抗原转化为胸腺依赖性（TD）抗原，从而在新生儿和婴儿中诱导免疫应答和免疫记忆。这种结合疫苗已被证明对新生儿和儿童中由包裹细菌引起的侵袭性疾病的最常见原因有效。将讨论这些方法以及目前疫苗开发中的其他几种方法。
Encapsulated bacteria are responsible for the majority of mortality among neonates and infants. The major components on the surface of these bacteria are polysaccharides which are important virulence factors. Immunity against these components protects against disease. However, most of the polysaccharides are thymus-independent (TI)-2 antigens which induce an inadequate immune response in neonates and infants. The mechanisms that are thought to play a role in the unresponsiveness of this age group to TI-2 stimuli will be discussed. The lack of immune response may be overcome by conjugating the polysaccharides to a carrier protein. This transforms bacterial polysaccharides from a TI-2 antigen into a thymus-dependent (TD) antigen, thereby inducing an immune response and immunological memory in neonates and infants. Such conjugated vaccines have been shown to be effective against the most common causes of invasive disease caused by encapsulated bacteria in neonates and children. These and several other approaches in current vaccine development will be discussed.
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3.6
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