Estimation of fractional myocardial blood volume and water exchange using ferumoxytol-enhanced magnetic resonance imaging.
Estimation of fractional myocardial blood volume and water exchange using ferumoxytol-enhanced magnetic resonance imaging.
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DOI：
10.1002/jmri.27494
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Nguyen KL
中科院分区：
文献类型：
--
作者：
Colbert CM;Thomas MA;Yan R;Radjenovic A;Finn JP;Hu P;Nguyen KL
使用费鲁莫托增强 MRI (FE-MRI) 估计的心肌血容量分数 (fMBV) 有可能在不依赖钆螯合物的情况下捕获对比稳态期间心肌灌注不足的血流动力学反应。 Ferumoxytol 具有较长的血管内半衰期，其用于稳态 MRI 的用途属于超适应症。优化和评估基于 FE-MRI 的 fMBV 估计二室模型。未来九头健康猪；一只猪患有人工诱导的单血管冠状动脉狭窄。使用 5(3)3(3)3 改良 Look-Locker 反转恢复 (MOLLI) 序列的 3.0T 临床磁体。在七次费鲁莫托输注（0.125 – 4.0 mg/kg）之前和之后的对比稳定状态下，使用 MOLLI 序列测量心肌纵向自旋晶格弛豫率 (R1)。使用两室模型估计 fMBV 和水交换。将模型拟合的 fMBV 与简单的快速交换 fMBV 近似值以及 Ferumoxytol R1 前后的百分比变化进行比较。研究了剂量欠采样方案以减少采集持续时间。通过单向方差分析 (ANOVA) 评估 fMBV 的变化。使用 Bland-Altman 分析评估快速交换 fMBV 和阿莫西托剂量欠采样。健康正常猪的平均心室中 fMBV 为 7.2 ± 1.4%，水交换率为 11.3 ± 5.1 s−1。 fMBV 存在受试者间变异（p <0.05），无分段变异（p=0.387）。八剂量和四剂量采样方案得出的 fMBV 没有显着偏差（平均差=0.07，p=0.541，一致性限为−1.04% [−1.45, −0.62%] 至 1.18% [0.77, 1.59%]）。一种冠状动脉狭窄猪模型的逐像素 fMBV 显示，缺血节段（心尖前部：11.90 ± 4.00%，心尖隔：16.10 ± 5.71%）相对于远端节段（心尖下：9.59 ± 3.35%，心尖外侧：9.38 ± 2.35%）fMBV 升高。基于使用 MOLLI 序列的 FE-MRI 的两室模型可以在缺血性心脏病研究中估计 fMBV。
Fractional myocardial blood volume (fMBV) estimated using ferumoxytol-enhanced MRI (FE-MRI) has the potential to capture a hemodynamic response to myocardial hypoperfusion during contrast steady state without reliance on gadolinium chelates. Ferumoxytol has a long intravascular half-life and its use for steady-state MRI is off-label. To optimize and evaluate a two-compartment model for estimation of fMBV based on FE-MRI. Prospective Nine healthy swine; one swine with artificially-induced single-vessel coronary stenosis. 3.0T clinical magnet using the 5(3)3(3)3 Modified Look-Locker Inversion Recovery (MOLLI) sequence. Myocardial longitudinal spin-lattice relaxation rate (R1) was measured using the MOLLI sequence before and at contrast steady state following seven ferumoxytol infusions (0.125 – 4.0 mg/kg). fMBV and water exchange were estimated using a two-compartment model. Model-fitted fMBV was compared to simple fast-exchange fMBV approximation and percent change in pre and post-ferumoxytol R1. Dose under-sampling schemes were investigated to reduce acquisition duration. Variation in fMBV was assessed with a one-way analysis of variance (ANOVA). Fast-exchange fMBV and ferumoxytol dose under-sampling were evaluated using Bland-Altman analysis. Healthy normal swine showed a mean mid-ventricular fMBV of 7.2 ± 1.4% and water exchange rate of 11.3 ± 5.1 s−1. There was inter-subject variation in fMBV (p <0.05) without segmental variation (p=0.387). fMBV derived from eight-dose and four-dose sampling schemes had no significant bias (mean difference =0.07, p=0.541, limits of agreement −1.04% [−1.45, −0.62%] to 1.18% [0.77, 1.59%]). Pixel-wise fMBV in one swine model with coronary artery stenosis showed elevated fMBV in ischemic segments (apical anterior: 11.90 ± 4.00%, apical septum: 16.10 ± 5.71%) relative to remote segments (apical inferior: 9.59 ± 3.35%, apical lateral: 9.38 ± 2.35%). A two-compartment model based on FE-MRI using the MOLLI sequence may enable estimation of fMBV in studies of ischemic heart disease.
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影响因子：
6.7
作者：
Knobloch, Gesine;Colgan, Timothy;Reeder, Scott B.
通讯作者：
Reeder, Scott B.
影响因子：
37.8
作者：
Cerqueira, MD;Weissman, NJ;Verani, MS
通讯作者：
Verani, MS
影响因子：
3.4
作者：
HAZLEWOOD, CF;CHANG, DC;WOESSNER, DE
通讯作者：
WOESSNER, DE
DOI：
10.3791/60729
发表时间：
2020-02-18
期刊：
Journal of visualized experiments : JoVE
影响因子：
--
作者：
Hollowed JJ;Colbert CM;Currier JW;Nguyen KL
通讯作者：
Nguyen KL
心肌血容量和流量在冠状动脉疾病中的作用：静息和充血期间的实验性 MRI 研究。
影响因子：
5.9
作者：
McCommis, Kyle S.;Goldstein, Thomas A.;Abendschein, Dana R.;Misselwitz, Bernd;Pilgram, Thomas;Gropler, Robert J.;Zheng, Jie
通讯作者：
Zheng, Jie