Downregulation of Pax3 expression correlates with acquired GFAP expression during NSC differentiation towards astrocytes
Downregulation of Pax3 expression correlates with acquired GFAP expression during NSC differentiation towards astrocytes
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Pax3 表达下调与 NSC 向星形胶质细胞分化过程中获得的 GFAP 表达相关
DOI：
10.1016/j.febslet.2011.02.034
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发表时间：
2011-04
期刊：
影响因子：
3.5
通讯作者：
Gu, Xiaosong
中科院分区：
文献类型：
--
作者：
Liu, Yan;Zhu, Hui;Liu, Mei;Du, Jinfeng;Qian, Yuyan;Wang, Yongjun;Ding, Fei;Gu, Xiaosong
胶质原纤维酸性蛋白（Glial fibrillary acid protein， GFAP）是中枢神经系统（CNS）成熟星形胶质细胞中主要的中间纤维，其转录调控机制尚不清楚。在本研究中，我们报道了配对盒3蛋白（paired box 3 protein, Pax3）作为GFAP转录的一种新的调控因子，它可以结合GFAP的启动子区域，在血清诱导的神经干细胞（NSCs）星形胶质细胞分化过程中下调GFAP水平。此外，Pax3过表达和抑制可分别抑制和促进NSC分化。这些数据表明Pax3在体外星形胶质细胞分化过程中负调控GFAP的表达。
Glial fibrillary acidic protein (GFAP) is a principal intermediate filament in mature astrocytes of the central nervous system (CNS), and the regulation of GFAP transcription has not been well understood yet. In the present study, we reported paired box 3 protein (Pax3) as a novel regulator of GFAP transcription, which could bind the promoter region of GFAP and down regulate the GFAP level during the serum-induced astrocyte differentiation of neural stem cells (NSCs). Moreover, the overexpression and suppression of Pax3 could inhibit and promote NSC differentiation, respectively. These data suggest that Pax3 negatively regulates GFAP expression during astrocyte differentiation in vitro.
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影响因子：
4.2
作者：
FEINSTEIN, DL;WEINMASTER, GA;MILNER, RJ
通讯作者：
MILNER, RJ
影响因子：
56.9
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