Counseling the patient with potentially HPV-related newly diagnosed head and neck cancer.

Counseling the patient with potentially HPV-related newly diagnosed head and neck cancer.
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DOI:
10.1007/s11912-013-0375-8
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发表时间:
2014-03
影响因子:
4.7
通讯作者:
Sikora, Andrew G.
Sikora, Andrew G.
中科院分区:
医学2区
文献类型:
--
作者:
Finnigan, John P., Jr.;Sikora, Andrew G.

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最近出现的由人乳头瘤病毒(HPV)感染引起的临床上独特的头颈癌(HNC)亚群,需要对新诊断的HNC患者的现有咨询模式进行批判性的重新评估。在这里,我们提出了患者咨询的结构框架,其中HPV检测被纳入和HPV状态的影响在多个医学和社会心理领域的背景下进行了讨论。我们努力在基于可获得的最佳科学证据提出建议和承认患者和提供者的不确定性之间保持平衡。我们预计,随着正在进行和计划中的前瞻性临床试验的数据变得可用,这些患者的标准诊断检查和治疗以及咨询指南将在未来几年迅速改变。
The recent emergence of a clinically distinct subset of head and neck cancers (HNC) caused by infection with the human papillomavirus (HPV) necessitates critical reevaluation of the existing counseling paradigm for patients with newly diagnosed HNC. Herein we propose a structural framework for patient counseling in which HPV testing is incorporated and the impact of HPV-status is discussed in the context of multiple medical and psychosocial domains. We strive to maintain a balance between making recommendations based on the best available scientific evidence and acknowledgment of uncertainty for both patients and providers. We anticipate that both the standard-of-care diagnostic workup and treatment, and counseling guidelines for these patients will change rapidly in the years ahead, as data from ongoing and planned prospective clinical trials become available.
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