Hybrid Capture II-based human papillomavirus detection, a sensitive test to detect in routine high-grade cervical lesions: a preliminary study on 1518 women.
Hybrid Capture II-based human papillomavirus detection, a sensitive test to detect in routine high-grade cervical lesions: a preliminary study on 1518 women.
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DOI：
10.1038/sj.bjc.6690523
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发表时间：
1999-07
影响因子：
8.8
通讯作者：
Birembaut, P
中科院分区：
文献类型：
--
作者：
Clavel, C;Masure, M;Bory, JP;Putaud, I;Mangeonjean, C;Lorenzato, M;Gabriel, R;Quereux, C;Birembaut, P
Hybrid Capture II (HC-II) 是一种商业人乳头瘤病毒 (HPV) 检测测试，旨在检测分为高风险和低风险组的 18 种 HPV 类型。我们使用这种检测方法对来自 1518 名未经选择的参加常规细胞学筛查的女性的 1647 处擦伤进行了检测，以检测经组织学证实的高级病变。还对 117 个新鲜锥形活检样本评估了该测试的可靠性。在 400 处擦伤 (24.3%) 中检测到 HPV DNA，其中 296 处擦伤含有高危 HPV (18.0%)。所有引起高级别病变的涂片均呈高危 HPV 阳性，并且在所有 34 例经组织学证实的高级别病变病例以及 70 份锥形活检样本中的 68 份（97.1%）显示高级别病变或浸润性癌的病例中均检测到高危 HPV。因此，敏感性优于细胞学的敏感性（85.3%）。然而，HC-II 检测提供的用于评估病毒载量的定量方法无法清楚地区分有或没有高度病变的病例。因此，建议将该测定与经典细胞学结合用于大规模筛查高级病变。 © 1999 癌症研究运动
Hybrid Capture II (HC-II) is a commercial human papillomavirus (HPV) detection test designed to detect 18 HPV types divided into high-risk and low-risk groups. We have tested 1647 scrapes from 1518 unselected women attending routine cytological screening by this assay for the detection of histologically proven high-grade lesions. The reliability of this test was also evaluated on 117 fresh cone biopsy samples. HPV DNA has been detected in 400 scrapes (24.3%), 296 containing a high-risk HPV (18.0%). All the smears evocative of high-grade lesions were positive for high-risk HPV, and high-risk HPV were detected in all the 34 cases presenting a histologically proven high-grade lesion and in 68 (97.1%) of the 70 cone biopsy samples showing a high-grade lesion or an invasive carcinoma. Thus, the sensitivity was superior to the sensitivity of cytology (85.3%). Nevertheless, the quantitative approach provided by the HC-II assay for the assessment of the viral load could not clearly distinguish among cases with or without high-grade lesions. Thus this assay is recommended for the screening of high-grade lesions on a large scale, in association with classic cytology. © 1999 Cancer Research Campaign
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影响因子：
8.8
作者：
CUZICK, J;TERRY, G;ANDERSON, M
通讯作者：
ANDERSON, M
DOI：
10.1016/0002-9378(95)90026-8
发表时间：
1995-03-01
影响因子：
9.8
作者：
COX, JT;LORINCZ, AT;KURMAN, RJ
通讯作者：
KURMAN, RJ
影响因子：
3.4
作者：
FARTHING, A;MASTERSON, P;VOUSDEN, KH
通讯作者：
VOUSDEN, KH
DOI：
10.1016/0002-9378(95)91473-0
发表时间：
1995-04-01
影响因子：
9.8
作者：
HATCH, KD;SCHNEIDER, A;ABDELNOUR, MW
通讯作者：
ABDELNOUR, MW
DOI：
10.1016/0002-9378(95)90629-0
发表时间：
1995-11-01
影响因子：
9.8
作者：
SUN, XW;FERENCZY, A;WRIGHT, TC
通讯作者：
WRIGHT, TC