The cognitive and neural underpinnings of discourse coherence in post-stroke aphasia.
The cognitive and neural underpinnings of discourse coherence in post-stroke aphasia.
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DOI：
10.1093/braincomms/fcac147
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发表时间：
2022
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
虽然受损的话语产生是失语症的突出特征之一，但只有少数研究涉及支持连贯话语产生的认知，语言和神经过程。在这项研究中，我们调查了认知和神经相关的话语连贯性在一个大的混合队列中风后失语症患者，包括第一个基于体素的病变症状映射的连贯性缺陷。使用不同的任务，话语反应收集了46例中风后失语症，包括广泛的分类和严重程度，和20个匹配的神经典型的控制。整体连贯性，定义为话语与预期话语主题相关的程度，使用先前验证的计算语言学方法进行估计。连贯性，然后与失语症的基本语言和认知成分确定使用广泛的神经心理电池。相对于神经典型的控制，失语症患者表现出受损的连贯性，他们的能力，以保持连贯的话语与他们的表现有关的其他语言成分：语音生产，流畅性和语义处理，而不是执行功能或运动语音。这些结果表明，核心语言成分的损伤在降低卒中后失语症的语篇连贯性方面发挥了作用。使用单变量和多变量方法的全脑体素病变症状映射确定了左前额叶皮层的贡献，特别是额下回（pars triangularis），话语连贯性。这些研究结果提供了收敛的证据额下回在保持话语连贯性的作用，这是一致的，在生产连接的语音和语义控制（组织和选择适当的上下文相关的概念），这一地区的既定作用。这些结果对理解脑卒中后失语症患者话语产生中断的根本原因做出了重要贡献。Alyahya等人发现中风后失语症的话语连贯性缺陷与一般语言成分（语音产生，流畅性和语义处理）而不是执行功能的损伤有关。他们发现，话语连贯性缺陷与左前额叶皮层，特别是额下回（三角区）的病变有关。
Although impaired discourse production is one of the prominent features of aphasia, only a handful of investigations have addressed the cognitive, linguistic and neural processes that support the production of coherent discourse. In this study, we investigated the cognitive and neural correlates of discourse coherence in a large mixed cohort of patients with post-stroke aphasia, including the first voxel-based lesion-symptom mapping of coherence deficits. Discourse responses using different tasks were collected from 46 patients with post-stroke aphasia, including a wide range of classifications and severity levels, and 20 matched neuro-typical controls. Global coherence, defined as the degree to which utterances related to the expected topic of discourse, was estimated using a previously validated computational linguistic approach. Coherence was then related to fundamental language and cognitive components in aphasia identified using an extensive neuropsychological battery. Relative to neuro-typical controls, patients with aphasia exhibited impaired coherence, and their ability to maintain coherent discourse was related to their performance on other language components: phonological production, fluency and semantic processing, rather than executive functions or motor speech. These results suggest that impairments in core language components play a role in reducing discourse coherence in post-stroke aphasia. Whole-brain voxel-wise lesion-symptom mapping using univariate and multivariate approaches identified the contribution of the left prefrontal cortex, and particularly the inferior frontal gyrus (pars triangularis), to discourse coherence. These findings provide convergent evidence for the role of the inferior frontal gyrus in maintaining discourse coherence, which is consistent with the established role of this region in producing connected speech and semantic control (organizing and selecting appropriate context-relevant concepts). These results make an important contribution to understanding the root causes of disrupted discourse production in post-stroke aphasia. Alyahya et al. found discourse coherence deficits in post-stroke aphasia to be related to impairments in general language components (phonological production, fluency and semantic processing) rather than executive functions. They found an association between discourse coherence deficits and lesions to the left prefrontal cortex, particularly the inferior frontal gyrus (pars triangularis).
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DOI：
10.1016/j.nicl.2017.12.009
发表时间：
2018
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Alyahya RSW;Halai AD;Conroy P;Lambon Ralph MA
通讯作者：
Lambon Ralph MA
影响因子：
5.3
作者：
Awad, Malaka;Warren, Jane E.;Wise, Richard J. S.
通讯作者：
Wise, Richard J. S.
影响因子：
3.2
作者：
Alyahya RSW;Halai AD;Conroy P;Lambon Ralph MA
通讯作者：
Lambon Ralph MA
影响因子：
4.8
作者：
DeMarco AT;Turkeltaub PE
通讯作者：
Turkeltaub PE
DOI：
10.1093/geronj/47.4.p266
发表时间：
1992-07-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
GLOSSER, G;DESER, T
通讯作者：
DESER, T